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Potential Effects of Pomegranate Polyphenols in Cancer Prevention and Therapy
المؤلفون المشاركون
Fimognari, Carmela
Turrini, Eleonora
Ferruzzi, Lorenzo
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-09
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
Cancer is the second leading cause of death and is becoming the leading one in old age.
Vegetable and fruit consumption is inversely associated with cancer incidence and mortality.
Currently, interest in a number of fruits high in polyphenols has been raised due to their reported chemopreventive and/or chemotherapeutic potential.
Pomegranate has been shown to exert anticancer activity, which is generally attributed to its high content of polyphenols.
This review provides a comprehensive analysis of known targets and mechanisms along with a critical evaluation of pomegranate polyphenols as future anticancer agents.
Pomegranate evokes antiproliferative, anti-invasive, and antimetastatic effects, induces apoptosis through the modulation of Bcl-2 proteins, upregulates p21 and p27, and downregulates cyclin-cdk network.
Furthermore, pomegranate blocks the activation of inflammatory pathways including, but not limited to, the NF-κB pathway.
The strongest evidence for its anticancer activity comes from studies on prostate cancer.
Accordingly, some exploratory clinical studies investigating pomegranate found a trend of efficacy in increasing prostate-specific antigen doubling time in patients with prostate cancer.
However, the genotoxicity reported for pomegranate raised certain concerns over its safety and an accurate assessment of the risk/benefit should be performed before suggesting the use of pomegranate or its polyphenols for cancer-related therapeutic purposes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Turrini, Eleonora& Ferruzzi, Lorenzo& Fimognari, Carmela. 2015. Potential Effects of Pomegranate Polyphenols in Cancer Prevention and Therapy. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-19.
https://search.emarefa.net/detail/BIM-1075816
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Turrini, Eleonora…[et al.]. Potential Effects of Pomegranate Polyphenols in Cancer Prevention and Therapy. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-19.
https://search.emarefa.net/detail/BIM-1075816
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Turrini, Eleonora& Ferruzzi, Lorenzo& Fimognari, Carmela. Potential Effects of Pomegranate Polyphenols in Cancer Prevention and Therapy. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-19.
https://search.emarefa.net/detail/BIM-1075816
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075816
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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