Octreotide Protects the Mouse Retina against Ischemic Reperfusion Injury through Regulation of Antioxidation and Activation of NF-κB
المؤلفون المشاركون
Wu, Dongdong
Wang, Jun
Li, Yanzhang
Sun, Ziqiang
Shen, Junsheng
Liu, Fang
Yang, Ruisheng
Ji, Shaoping
Ji, Ailing
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-14
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Somatostatin (SST), an endogenous peptide, may exert anti-inflammatory and neuroprotective effects on retinal injury induced by ischemia.
Retinal ischemic reperfusion (I/R) injury always produces many reactive oxygen species (ROS), which can aggravate the tissue damage.
The effects of octreotide (OCT), a SST analogue, on retinal I/R injury and ROS formation, are not very clear.
In this study, we observed the effects of OCT on morphological changes, oxidative stress, and cell death, induced by retinal I/R injury.
The activation of nuclear factor κB (NF-κB) and intercellular adhesion molecule-1 (ICAM-1) were further evaluated in I/R retina treated with or without OCT.
The retinal layer thickness was increased at 1 day after I/R and decreased at 7 days after I/R P<0.05.
This effect was associated with increase in MDA and ROS levels P<0.05.
The Tunel-positive cells increased and the number of ganglion cell layer (GCL) neurons decreased significantly after I/R injury.
The expression of p-p65 and ICAM-1 increased significantly in I/R retinas P<0.05.
Each effect was markedly attenuated by application of OCT.
These data indicate that OCT protects the retina against retinal I/R damage, which could be through inhibition of oxidative stress and downregulation of NF-κB and ICAM-1 expression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Jun& Sun, Ziqiang& Shen, Junsheng& Wu, Dongdong& Liu, Fang& Yang, Ruisheng…[et al.]. 2015. Octreotide Protects the Mouse Retina against Ischemic Reperfusion Injury through Regulation of Antioxidation and Activation of NF-κB. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075826
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Jun…[et al.]. Octreotide Protects the Mouse Retina against Ischemic Reperfusion Injury through Regulation of Antioxidation and Activation of NF-κB. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1075826
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Jun& Sun, Ziqiang& Shen, Junsheng& Wu, Dongdong& Liu, Fang& Yang, Ruisheng…[et al.]. Octreotide Protects the Mouse Retina against Ischemic Reperfusion Injury through Regulation of Antioxidation and Activation of NF-κB. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075826
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075826
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر