Biomolecular Modulation of Neurodegenerative Events during Ageing
المؤلفون المشاركون
Pescosolido, Nicola
Scarsella, Gianfranco
Librando, Aloisa
Nebbioso, Marcella
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-10-25
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The objective is to assess the modulation of retinal and optic nerve degenerative events induced by the combination of α-lipoic acid (ALA) and superoxide dismutase (SOD) in an animal model of ageing.
For this study, 24 male Wistar-Harlan strain rats were left to age for up to 24 months.
One group of rats was subjected to a diet supplemented with ALA and SOD for 8 weeks, while another group was used as a positive control and not subjected to any dietary treatment.
To assess the cytoprotective effects of the antioxidants, a morphological analysis was carried out on sections of retina and optic nerve head, stained with haematoxylin-eosin, followed by an analysis of the modifications to nuclear DNA detected by the TUNEL technique.
The lipid peroxidation assay was used to assess the damage induced by oxidative stress at cell membrane level.
The molecules involved in apoptosis mediated by oxidative stress, such as caspase-3 and inducible nitric oxide synthase, were also assayed by immunolocalization and western blot.
ALA and SOD are able to counteract senile neurodegenerative deterioration to the retina and optic nerve.
Indeed, the combination of these antioxidant molecules can reduce oxidative stress levels and thus prevent both nuclear degradation and subsequent cell death.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nebbioso, Marcella& Scarsella, Gianfranco& Librando, Aloisa& Pescosolido, Nicola. 2015. Biomolecular Modulation of Neurodegenerative Events during Ageing. Oxidative Medicine and Cellular Longevity،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075829
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nebbioso, Marcella…[et al.]. Biomolecular Modulation of Neurodegenerative Events during Ageing. Oxidative Medicine and Cellular Longevity No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1075829
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nebbioso, Marcella& Scarsella, Gianfranco& Librando, Aloisa& Pescosolido, Nicola. Biomolecular Modulation of Neurodegenerative Events during Ageing. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1075829
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075829
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر