Thioredoxin 1 in Prostate Tissue Is Associated with Gleason Score, Erythrocyte Antioxidant Enzyme Activity, and Dietary Antioxidants
المؤلفون المشاركون
Su, L. Joseph
Chen, Ming-Hui
Vance, Terrence M.
Azabdaftari, Gissou
Pop, Elena A.
Lee, Sang Gil
Koo, Sung I.
Chun, Ock K.
Arab, Lenore
Mohler, James L.
Steck, Susan E.
Bensen, Jeannette T.
Fontham, Elizabeth T. H.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-18
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Prostate cancer is the most common noncutaneous cancer and second leading cause of cancer-related mortality in men in the US.
Growing evidence suggests that oxidative stress is involved in prostate cancer.
Methods.
In this study, thioredoxin 1 (Trx 1), an enzyme and subcellular indicator of redox status, was measured in prostate biopsy tissue from 55 men from the North Carolina-Louisiana Prostate Cancer Project.
A pathologist blindly scored levels of Trx 1.
The association between Trx 1 and the Gleason score, erythrocyte antioxidant enzyme activity, and dietary antioxidant intake was determined using Fisher’s exact test.
Results.
Trx 1 levels in benign prostate tissue in men with incident prostate cancer were positively associated with the Gleason score (P=0.01) and inversely associated with dietary antioxidant intake (P=0.03).
In prostate cancer tissue, Trx 1 levels were associated with erythrocyte glutathione peroxidase activity (P=0.01).
No association was found for other erythrocyte enzymes.
Greater Gleason score of malignant tissue corresponds to a greater difference in Trx 1 levels between malignant and benign tissue (P=0.04).
Conclusion.
These results suggest that the redox status of prostate tissue is associated with prostate cancer grade and both endogenous and exogenous antioxidants.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vance, Terrence M.& Azabdaftari, Gissou& Pop, Elena A.& Lee, Sang Gil& Su, L. Joseph& Fontham, Elizabeth T. H.…[et al.]. 2015. Thioredoxin 1 in Prostate Tissue Is Associated with Gleason Score, Erythrocyte Antioxidant Enzyme Activity, and Dietary Antioxidants. Prostate Cancer،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075840
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vance, Terrence M.…[et al.]. Thioredoxin 1 in Prostate Tissue Is Associated with Gleason Score, Erythrocyte Antioxidant Enzyme Activity, and Dietary Antioxidants. Prostate Cancer No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1075840
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vance, Terrence M.& Azabdaftari, Gissou& Pop, Elena A.& Lee, Sang Gil& Su, L. Joseph& Fontham, Elizabeth T. H.…[et al.]. Thioredoxin 1 in Prostate Tissue Is Associated with Gleason Score, Erythrocyte Antioxidant Enzyme Activity, and Dietary Antioxidants. Prostate Cancer. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1075840
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075840
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر