Salivary Acetylcholinesterase Activity Is Increased in Parkinson’s Disease: A Potential Marker of Parasympathetic Dysfunction
المؤلفون المشاركون
Fedorova, Tatyana
Knudsen, Cindy Soendersoe
Mouridsen, Kim
Nexo, Ebba
Borghammer, Per
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-12
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Introduction.
Decreased salivary flow and xerostomia are frequent findings in Parkinson’s disease (PD), possibly caused by alterations in the parasympathetic tonus.
Here we explore salivary acetylcholinesterase (AChE) activity as a potential biomarker in PD.
Methods.
We measured salivary flow, AChE activity, and total protein concentration in 30 PD patients and 49 healthy controls.
We also performed exploratory correlation analyses with disease duration, motor symptom severity, autonomic complaints, and other nonmotor symptoms.
Results.
PD patients displayed significantly decreased salivary flow rate, significantly increased salivary AChE activity, and total protein concentration.
Importantly, the AChE activity/total protein ratio was significantly increased in PD patients, suggesting that increased AChE activity cannot be explained solely by upconcentration of saliva.
The Unified PD Rating Scale (UPDRS) score displayed significant correlation with total salivary protein (P=0.002) and near-significant correlation with salivary flow (P=0.07).
Color vision test scores were also significantly correlated with AChE activity (P=0.04) and total protein levels (P=0.002).
Conclusion.
Salivary AChE activity is increased in PD patients compared to healthy controls.
Future studies are needed to elucidate whether this parameter reflects the extent of neuronal damage and parasympathetic denervation in the salivary glands of PD patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fedorova, Tatyana& Knudsen, Cindy Soendersoe& Mouridsen, Kim& Nexo, Ebba& Borghammer, Per. 2015. Salivary Acetylcholinesterase Activity Is Increased in Parkinson’s Disease: A Potential Marker of Parasympathetic Dysfunction. Parkinson’s Disease،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1075848
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fedorova, Tatyana…[et al.]. Salivary Acetylcholinesterase Activity Is Increased in Parkinson’s Disease: A Potential Marker of Parasympathetic Dysfunction. Parkinson’s Disease No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1075848
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fedorova, Tatyana& Knudsen, Cindy Soendersoe& Mouridsen, Kim& Nexo, Ebba& Borghammer, Per. Salivary Acetylcholinesterase Activity Is Increased in Parkinson’s Disease: A Potential Marker of Parasympathetic Dysfunction. Parkinson’s Disease. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1075848
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075848
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر