Diffusion Kurtosis Imaging of Substantia Nigra Is a Sensitive Method for Early Diagnosis and Disease Evaluation in Parkinson’s Disease
المؤلفون المشاركون
Zhang, Guohua
Zhang, Yuhu
Zhang, Chengguo
Wang, Yukai
Ma, Guixian
Nie, Kun
Liu, Jianping
Wang, Lijuan
Xie, Haiqun
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-03
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
To diagnose Parkinson disease (PD) in an early stage and accurately evaluate severity, it is important to develop a sensitive method for detecting structural changes in the substantia nigra (SN).
Method.
Seventy-two untreated patients with early PD and 72 healthy controls underwent diffusion tensor and diffusion kurtosis imaging.
Regions of interest were drawn in the rostral, middle, and caudal SN by two blinded and independent raters.
Mean kurtosis (MK) and fractional anisotropy in the SN were compared between the groups.
Receiver operating characteristic (ROC) and Spearman correlation analyses were used to compare the diagnostic accuracy and correlate imaging findings with Hoehn-Yahr (H-Y) staging and part III of the Unified Parkinson’s Disease Rating Scale (UPDRS-III).
Result.
MK in the SN was increased significantly in PD patients compared with healthy controls.
The area under the ROC curve was 0.976 for MK in the SN (sensitivity, 0.944; specificity, 0.917).
MK in the SN had a positive correlation with H-Y staging and UPDRS-III scores.
Conclusion.
Diffusion kurtosis imaging is a sensitive method for PD diagnosis and severity evaluation.
MK in the SN is a potential biomarker for imaging studies of early PD that can be widely used in clinic.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Guohua& Zhang, Yuhu& Zhang, Chengguo& Wang, Yukai& Ma, Guixian& Nie, Kun…[et al.]. 2015. Diffusion Kurtosis Imaging of Substantia Nigra Is a Sensitive Method for Early Diagnosis and Disease Evaluation in Parkinson’s Disease. Parkinson’s Disease،Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1075854
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Guohua…[et al.]. Diffusion Kurtosis Imaging of Substantia Nigra Is a Sensitive Method for Early Diagnosis and Disease Evaluation in Parkinson’s Disease. Parkinson’s Disease No. 2015 (2015), pp.1-5.
https://search.emarefa.net/detail/BIM-1075854
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Guohua& Zhang, Yuhu& Zhang, Chengguo& Wang, Yukai& Ma, Guixian& Nie, Kun…[et al.]. Diffusion Kurtosis Imaging of Substantia Nigra Is a Sensitive Method for Early Diagnosis and Disease Evaluation in Parkinson’s Disease. Parkinson’s Disease. 2015. Vol. 2015, no. 2015, pp.1-5.
https://search.emarefa.net/detail/BIM-1075854
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075854
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر