The Diagnostic and Differential Diagnosis Utility of Cerebrospinal Fluid α-Synuclein Levels in Parkinson’s Disease: A Meta-Analysis
المؤلفون المشاركون
Zhou, Bo
Wen, Min
Yu, Wen-Feng
Zhang, Chun-Lin
Jiao, Ling
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-29
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Several recent studies showed that α-syn might be a potential diagnostic biomarker for PD in human cerebrospinal fluid (CSF), but the results were inconsistent.
The purpose of this meta-analysis was to investigate the diagnostic and differential diagnosis efficacy of CSF α-syn in PD.
Studies which measured CSF α-syn or α-syn oligomers in patients with PD and met the inclusion criteria were included in the analysis.
Results of the meta-analysis indicated that mean concentration of CSF α-syn was significantly lower in PD compared to controls and significantly higher in PD compared to multiple system atrophy (MSA).
No significant difference in mean concentration of CSF α-syn was found between PD and dementia with Lewy bodies (DLB).
Mean concentration of CSF α-syn was slightly decreased in PD compared to progressive supranuclear palsy (PSP).
Mean concentration of CSF α-syn oligomers was significantly higher in PD than control.
These results support the findings that CSF α-syn may be a potential diagnostic and differential diagnosis biomarker in PD compared to control and MSA but not DLB.
Furthermore, α-syn oligomer may represent a better biomarker for diagnosis of PD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhou, Bo& Wen, Min& Yu, Wen-Feng& Zhang, Chun-Lin& Jiao, Ling. 2015. The Diagnostic and Differential Diagnosis Utility of Cerebrospinal Fluid α-Synuclein Levels in Parkinson’s Disease: A Meta-Analysis. Parkinson’s Disease،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075895
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhou, Bo…[et al.]. The Diagnostic and Differential Diagnosis Utility of Cerebrospinal Fluid α-Synuclein Levels in Parkinson’s Disease: A Meta-Analysis. Parkinson’s Disease No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1075895
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhou, Bo& Wen, Min& Yu, Wen-Feng& Zhang, Chun-Lin& Jiao, Ling. The Diagnostic and Differential Diagnosis Utility of Cerebrospinal Fluid α-Synuclein Levels in Parkinson’s Disease: A Meta-Analysis. Parkinson’s Disease. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1075895
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075895
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر