The Role of α-Synuclein and LRRK2 in Tau Phosphorylation

الملخص EN

There is now a considerable body of experimental evidence that Parkinson’s disease arises through physiological interaction of causative molecules, leading to tau pathology.

In this review, we discuss the physiological role of α-synuclein and LRRK2 in the abnormal phosphorylation of tau.

In addition, as recent reports have indicated that heat shock proteins- (HSPs-) inducing drugs can help to ameliorate neurodegenerative diseases associated with tau pathology, we also discuss therapeutic strategies for PD focusing on inhibition of α-synuclein- and LRRK2-associated tau phosphorylation by HSPs.