Pharmacokinetic Study and Optimal Formulation of New Anti-Parkinson Natural Compound Schisantherin A
المؤلفون المشاركون
Lee, Simon Ming-Yuen
Zhang, Zai Jun
Zheng, Ying
Guo, Baojian
Sa, Fei
Li, Sai
Chan, Hok Man
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-17
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Our recent studies showed that schisantherin A (StA) is a promising candidate for PD treatment, but the pharmacokinetic profile of StA is largely unknown.
The effects of different formulations on the pharmacokinetics and bioavailability of StA were investigated by HPLC equipped with a vacuum degasser, a quaternary pump, a manual sampler, and an ultraviolet detector.
The absolute bioavailability of StA in nanoemulsion formulation was significantly increased from 4.3% to 47.3%.
To the best of our knowledge, this is the first report of absolute bioavailability for StA in rats and successful increase of bioavailability of StA by nanoemulsion formulation.
The pharmacokinetic profiles of StA could be significantly improved by a safe nanoemulsion formulation.
This study provides a successful example of advanced delivery system for improving the bioavailability of potential central nervous system (CNS) drug candidate with poor solubility.
This novel approach could be an effective alternative solution to overcome the shortcomings of conventional poor drug delivery of CNS drugs.
The results of present study not only indicate that StA has potential to be developed as a promising oral therapeutic agent for the management of PD but also shed light on novel way to improve bioavailability of PD drugs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sa, Fei& Guo, Baojian& Li, Sai& Zhang, Zai Jun& Chan, Hok Man& Zheng, Ying…[et al.]. 2015. Pharmacokinetic Study and Optimal Formulation of New Anti-Parkinson Natural Compound Schisantherin A. Parkinson’s Disease،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1075928
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sa, Fei…[et al.]. Pharmacokinetic Study and Optimal Formulation of New Anti-Parkinson Natural Compound Schisantherin A. Parkinson’s Disease No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1075928
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sa, Fei& Guo, Baojian& Li, Sai& Zhang, Zai Jun& Chan, Hok Man& Zheng, Ying…[et al.]. Pharmacokinetic Study and Optimal Formulation of New Anti-Parkinson Natural Compound Schisantherin A. Parkinson’s Disease. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1075928
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1075928
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر