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Intraoperative Radiotherapy in the Management of Locally Recurrent Extremity Soft Tissue Sarcoma
المؤلفون المشاركون
Horvai, Andrew E.
Tinkle, Christopher L.
Weinberg, Vivian
Braunstein, Steve E.
Wustrack, Rosanna
Jahan, Thierry
O’Donnell, Richard J.
Gottschalk, Alexander R.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-08-09
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Purpose.
To investigate the efficacy and morbidity of limb-sparing surgery with intraoperative radiotherapy (IORT) for patients with locally recurrent extremity soft tissue sarcoma (ESTS).
Methods and Materials.
Twenty-six consecutively treated patients were identified in a single institution retrospective analysis of patients with locally recurrent ESTS treated with IORT following salvage limb-sparing resection from May 2000 to July 2011.
Fifteen (58%) patients received external beam radiotherapy (EBRT) prior to recurrence (median dose 63 Gy), while 11 (42%) patients received EBRT following IORT (median dose 52 Gy).
The Kaplan-Meier product limit method was used to estimate disease control and survival and subsets were compared using a log rank statistic, Cox’s regression model was used to determine independent predictors of disease outcome, and toxicity was reported according to CTCAE v4.0 guidelines.
Results.
With a median duration of follow-up from surgery and IORT of 34.9 months (range: 4 to 139 mos.), 10 patients developed a local recurrence with 4 subsequently undergoing amputation.
The 5-year estimate for local control (LC) was 58% (95% CI: 36–75%), for amputation-free was 81% (95% CI: 57–93%), for metastasis-free control (MFC) was 56% (95% CI: 31–75%), for disease-free survival (DFS) was 35% (95% CI: 17–54%), and for overall survival (OS) was 50% (95% CI: 24–71%).
Prior EBRT did not appear to influence disease control (LC, p = 0.74 ; MFC, p = 0.66 ) or survival (DFS, p = 0.16 ; OS, p = 0.58 ).
Grade 3 or higher acute and late toxicities were reported for 6 (23%) and 8 (31%) patients, respectively.
The frequency of both acute and late grade 3 or higher toxicities occurred equally between patients who received EBRT prior to or after IORT.
Conclusions.
IORT in combination with oncologic resection of recurrent ESTS yields good rates of local control and limb-salvage with acceptable morbidity.
Within the limitations of small subsets, these data suggest that prior EBRT does not significantly influence disease control or toxicity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tinkle, Christopher L.& Weinberg, Vivian& Braunstein, Steve E.& Wustrack, Rosanna& Horvai, Andrew E.& Jahan, Thierry…[et al.]. 2015. Intraoperative Radiotherapy in the Management of Locally Recurrent Extremity Soft Tissue Sarcoma. Complexity،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1076108
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tinkle, Christopher L.…[et al.]. Intraoperative Radiotherapy in the Management of Locally Recurrent Extremity Soft Tissue Sarcoma. Complexity No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1076108
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tinkle, Christopher L.& Weinberg, Vivian& Braunstein, Steve E.& Wustrack, Rosanna& Horvai, Andrew E.& Jahan, Thierry…[et al.]. Intraoperative Radiotherapy in the Management of Locally Recurrent Extremity Soft Tissue Sarcoma. Complexity. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1076108
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1076108
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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