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Immune Suppressive Effects of Tonsil-Derived Mesenchymal Stem Cells on Mouse Bone-Marrow-Derived Dendritic Cells
المؤلفون المشاركون
Woo, So-Yeon
Park, Minhwa
Kim, Yu-Hee
Ryu, Jung-Hwa
Ryu, Kyung-Ha
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-16
دولة النشر
مصر
عدد الصفحات
12
الملخص EN
Mesenchymal stem cells (MSCs) are considered valuable sources for cell therapy because of their immune regulatory function.
Here, we investigated the effects of tonsil-derived MSCs (T-MSCs) on the differentiation, maturation, and function of dendritic cells (DCs).
We examined the effect of T-MSCs on differentiation and maturation of bone-marrow- (BM-) derived monocytes into DCs and we found suppressive effect of T-MSCs on DCs via direct contact as well as soluble mediators.
Moreover, T cell proliferation, normally increased in the presence of DCs, was inhibited by T-MSCs.
Differentiation of CD4+ T cell subsets by the DC-T cell interaction also was inhibited by T-MSCs.
The soluble mediators suppressed by T-MSCs were granulocyte-macrophage colony-stimulating factor (GM-CSF), RANTES, interleukin-6 (IL-6), and monocyte chemoattractant protein-1 (MCP-1).
Taken together, T-MSCs exert immune modulatory function via suppression of the differentiation, maturation, and function of BM-derived DCs.
Our data suggests that T-MSCs could be used as a novel source of stem cell therapy as immune modulators.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Park, Minhwa& Kim, Yu-Hee& Ryu, Jung-Hwa& Woo, So-Yeon& Ryu, Kyung-Ha. 2015. Immune Suppressive Effects of Tonsil-Derived Mesenchymal Stem Cells on Mouse Bone-Marrow-Derived Dendritic Cells. Stem Cells International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1076121
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Park, Minhwa…[et al.]. Immune Suppressive Effects of Tonsil-Derived Mesenchymal Stem Cells on Mouse Bone-Marrow-Derived Dendritic Cells. Stem Cells International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1076121
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Park, Minhwa& Kim, Yu-Hee& Ryu, Jung-Hwa& Woo, So-Yeon& Ryu, Kyung-Ha. Immune Suppressive Effects of Tonsil-Derived Mesenchymal Stem Cells on Mouse Bone-Marrow-Derived Dendritic Cells. Stem Cells International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1076121
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1076121
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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