MicroRNA Regulation of Brain Tumour Initiating Cells in Central Nervous System Tumours
المؤلفون المشاركون
Garg, Neha
Vijayakumar, Thusyanth
Bakhshinyan, David
Venugopal, Chitra
Singh, Sheila K.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-03
دولة النشر
مصر
عدد الصفحات
15
الملخص EN
CNS tumours occur in both pediatric and adult patients and many of these tumours are associated with poor clinical outcome.
Due to a paradigm shift in thinking for the last several years, these tumours are now considered to originate from a small population of stem-like cells within the bulk tumour tissue.
These cells, termed as brain tumour initiating cells (BTICs), are perceived to be regulated by microRNAs at the posttranscriptional/translational levels.
Proliferation, stemness, differentiation, invasion, angiogenesis, metastasis, apoptosis, and cell cycle constitute some of the significant processes modulated by microRNAs in cancer initiation and progression.
Characterization and functional studies on oncogenic or tumour suppressive microRNAs are made possible because of developments in sequencing and microarray techniques.
In the current review, we bring recent knowledge of the role of microRNAs in BTIC formation and therapy.
Special attention is paid to two highly aggressive and well-characterized brain tumours: gliomas and medulloblastoma.
As microRNA seems to be altered in the pathogenesis of many human diseases, “microRNA therapy” may now have potential to improve outcomes for brain tumour patients.
In this rapidly evolving field, further understanding of miRNA biology and its contribution towards cancer can be mined for new therapeutic tools.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Garg, Neha& Vijayakumar, Thusyanth& Bakhshinyan, David& Venugopal, Chitra& Singh, Sheila K.. 2015. MicroRNA Regulation of Brain Tumour Initiating Cells in Central Nervous System Tumours. Stem Cells International،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1076128
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Garg, Neha…[et al.]. MicroRNA Regulation of Brain Tumour Initiating Cells in Central Nervous System Tumours. Stem Cells International No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1076128
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Garg, Neha& Vijayakumar, Thusyanth& Bakhshinyan, David& Venugopal, Chitra& Singh, Sheila K.. MicroRNA Regulation of Brain Tumour Initiating Cells in Central Nervous System Tumours. Stem Cells International. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1076128
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1076128
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر