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Osteopontin Overexpression Induced Tumor Progression and Chemoresistance to Oxaliplatin through Induction of Stem-Like Properties in Human Colorectal Cancer
المؤلفون المشاركون
Ng, Lui
Chow, Ariel Ka-Man
Poon, Ronnie Tung-Ping
Foo, Dominic
Wan, Timothy Ming-Hun
Iyer, Deepak
Chen, Guanghua
Lo, Oswens Siu-Hung
Man, Johnny Hon-Wai
Pang, Roberta Wen-Chi
Poon, Jensen Tung-Chung
Law, Wai-Lun
Yau, Thomas
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-27
دولة النشر
مصر
عدد الصفحات
8
الملخص EN
Colorectal cancer (CRC) is one of the most common and fatal malignancies worldwide.
The poor prognosis of colorectal cancer patients is due to development of chemoresistance and cancer metastasis.
Recently osteopontin (OPN) has been associated with stem-like properties in colorectal cancer.
This study further examined the clinicopathological significance of OPN in CRC and its effect on chemoresistance and transcription of stem cell markers.
We examined the transcription level of OPN in 84 CRC patients and correlated the expression with their clinicopathological parameters.
The associations of OPN overexpression with transcription of stem cell markers and response to chemotherapy in DLD1-OPN overexpressing clones and CRC patients were also investigated.
Our results showed that OPN was significantly overexpressed in CRC, and its overexpression correlated with tumor stage and poor prognosis.
Overexpression of CRC induced OCT4 and SOX2 expression in vitro and correlated with SOX2 overexpression in CRC patients.
In addition, DLD1-OPN overexpressing cells showed enhanced ability to survive upon oxaliplatin treatment, and OPN expression was higher in CRC patients who were resistant to oxaliplatin-involved chemotherapy treatment.
Thus, CRC cells overexpressing OPN demonstrated stem-like properties and OPN inhibition is a potential therapeutic approach to combat CRC progression and chemoresistance.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ng, Lui& Wan, Timothy Ming-Hun& Chow, Ariel Ka-Man& Iyer, Deepak& Man, Johnny Hon-Wai& Chen, Guanghua…[et al.]. 2015. Osteopontin Overexpression Induced Tumor Progression and Chemoresistance to Oxaliplatin through Induction of Stem-Like Properties in Human Colorectal Cancer. Stem Cells International،Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1076169
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ng, Lui…[et al.]. Osteopontin Overexpression Induced Tumor Progression and Chemoresistance to Oxaliplatin through Induction of Stem-Like Properties in Human Colorectal Cancer. Stem Cells International No. 2015 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1076169
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ng, Lui& Wan, Timothy Ming-Hun& Chow, Ariel Ka-Man& Iyer, Deepak& Man, Johnny Hon-Wai& Chen, Guanghua…[et al.]. Osteopontin Overexpression Induced Tumor Progression and Chemoresistance to Oxaliplatin through Induction of Stem-Like Properties in Human Colorectal Cancer. Stem Cells International. 2015. Vol. 2015, no. 2015, pp.1-8.
https://search.emarefa.net/detail/BIM-1076169
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1076169
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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