Bone Marrow-Derived Mesenchymal Stem Cells Repair Necrotic Pancreatic Tissue and Promote Angiogenesis by Secreting Cellular Growth Factors Involved in the SDF-1αCXCR4 Axis in Rats
المؤلفون المشاركون
He, Zhigang
Hua, Jie
Song, Zhenshun
Qian, Daohai
Gong, Jian
Lin, Shengping
Xu, Chenglei
Meng, Hongbo
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-20، 20ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-02-25
دولة النشر
مصر
عدد الصفحات
20
الملخص EN
Acute pancreatitis (AP), a common acute abdominal disease, 10%–20% of which can evolve into severe acute pancreatitis (SAP), is of significant morbidity and mortality.
Bone marrow-derived mesenchymal stem cells (BMSCs) have been reported to have a potential therapeutic role on SAP, but the specific mechanism is unclear.
Therefore, we conducted this experiment to shed light on the probable mechanism.
We validated that SDF-1α significantly stimulated the expressions of VEGF, ANG-1, HGF, TGF-β, and CXCR4 in BMSCs, which were inhibited by its receptor agonist, AMD3100.
The capacities of proliferation, migration, and repair of human umbilical vein endothelial cells were enhanced by BMSCs supernatant.
Meanwhile, BMSCs supernatant could also promote angiogenesis, especially after the stimulation with SDF-1α.
In vivo, the migration of BMSCs was regulated by SDF-1α/CXCR4 axis.
Moreover, transplanted BMSCs could significantly alleviate SAP, reduce the systematic inflammation (TNF-α↓, IL-1β↓, IL-6↓, IL-4↑, IL-10↑, and TGF-β↑), and promote tissue repair and angiogenesis (VEGF↑, ANG-1↑, HGF↑, TGF-β↑, and CD31↑), compared with the SAP and anti-CXCR4 groups.
Taken together, the results showed that BMSCs ameliorated SAP and the SDF-1α/CXCR4 axis was involved in the repair and regeneration process.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Qian, Daohai& Gong, Jian& He, Zhigang& Hua, Jie& Lin, Shengping& Xu, Chenglei…[et al.]. 2015. Bone Marrow-Derived Mesenchymal Stem Cells Repair Necrotic Pancreatic Tissue and Promote Angiogenesis by Secreting Cellular Growth Factors Involved in the SDF-1αCXCR4 Axis in Rats. Stem Cells International،Vol. 2015, no. 2015, pp.1-20.
https://search.emarefa.net/detail/BIM-1076182
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Qian, Daohai…[et al.]. Bone Marrow-Derived Mesenchymal Stem Cells Repair Necrotic Pancreatic Tissue and Promote Angiogenesis by Secreting Cellular Growth Factors Involved in the SDF-1αCXCR4 Axis in Rats. Stem Cells International No. 2015 (2015), pp.1-20.
https://search.emarefa.net/detail/BIM-1076182
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Qian, Daohai& Gong, Jian& He, Zhigang& Hua, Jie& Lin, Shengping& Xu, Chenglei…[et al.]. Bone Marrow-Derived Mesenchymal Stem Cells Repair Necrotic Pancreatic Tissue and Promote Angiogenesis by Secreting Cellular Growth Factors Involved in the SDF-1αCXCR4 Axis in Rats. Stem Cells International. 2015. Vol. 2015, no. 2015, pp.1-20.
https://search.emarefa.net/detail/BIM-1076182
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1076182
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر