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Efficacy of Surgery Combined with Autologous Bone Marrow Stromal Cell Transplantation for Treatment of Intracerebral Hemorrhage
المؤلفون المشاركون
Zhu, Jianxin
Xiao, Yilei
Li, Zhongmin
Han, Fabin
Xiao, Taiwu
Zhang, Zhiti
Geng, Fengyang
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-09
دولة النشر
مصر
عدد الصفحات
7
الملخص EN
Bone marrow stromal cells (BMSCs) may differentiate into nerve cells under a certain condition; however, the clinical application for treating nervous system disease remains unclear.
The aim is to assess the safety profile, feasibility, and effectiveness of surgery combined with autologous BMSCs transplantation for treating ICH.
206 ICH patients who had received surgical procedure were divided into transplantation ( n = 110 ) or control group ( n = 96 ).
For transplantation group, BMSCs were injected into the perihemorrhage area in the base ganglia through an intracranial drainage tube 5.5 (3.01–6.89) days after surgery, followed by a second injection into the subarachnoid space through lumbar puncture 4 weeks later.
Neurologic impairment and daily activities were assessed with National Institute Stroke Scale (NIHSS), Barthel index, and Rankin scale before transplantation and 6 months and 12 months after transplantation.
Our results revealed that, compared with control group, NIHSS score and Rankin scale were both significantly decreased but Barthel index was increased in transplantation group after 6 months.
Interestingly, no significant difference was observed between 12 months and 6 months.
No transplantation-related adverse effects were investigated during follow-up assessments.
Our findings suggest that surgery combined with autologous BMSCs transplantation is safe for treatment of ICH, providing short-term therapeutic benefits.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhu, Jianxin& Xiao, Yilei& Li, Zhongmin& Han, Fabin& Xiao, Taiwu& Zhang, Zhiti…[et al.]. 2015. Efficacy of Surgery Combined with Autologous Bone Marrow Stromal Cell Transplantation for Treatment of Intracerebral Hemorrhage. Stem Cells International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1076183
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhu, Jianxin…[et al.]. Efficacy of Surgery Combined with Autologous Bone Marrow Stromal Cell Transplantation for Treatment of Intracerebral Hemorrhage. Stem Cells International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1076183
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhu, Jianxin& Xiao, Yilei& Li, Zhongmin& Han, Fabin& Xiao, Taiwu& Zhang, Zhiti…[et al.]. Efficacy of Surgery Combined with Autologous Bone Marrow Stromal Cell Transplantation for Treatment of Intracerebral Hemorrhage. Stem Cells International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1076183
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1076183
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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