Effect of Increasing Doses of γ-Radiation on Bone Marrow Stromal Cells Grown on Smooth and Rough Titanium Surfaces
المؤلفون المشاركون
Huang, Bo
Guang, Mengkai
Ye, Jun
Gong, Ping
Tang, Hua
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-15
دولة النشر
مصر
عدد الصفحات
11
الملخص EN
Radiation therapy for oral and maxillofacial tumors could damage bone marrow stromal cells (BMSCs) in jaw, which caused dental implant failure.
However, how radiation affects BMSCs on SLA (sandblasted with large-grits, acid-etched) surfaces is still unknown.
The aim of this study was to investigate effect of different dose of γ-radiation on BMSCs on SLA and PT (polished titanium) surfaces.
Rat BMSCs were radiated with 2, 4, and 8 Gy γ-radiation and then seeded on both surfaces.
Cell adhesion, spreading, and proliferation were tested.
The osteogenesis and the adipogenesis ability were examined by Alizarin-Red and Oil-Red staining, respectively.
Real-time PCR was performed to detect osteogenic (osteocalcin, OCN; runt-related transcription factor 2, Runx2) and adipogenic (peroxisome proliferator-activated receptor gamma, PPARγ) gene expression at days 7 and 14 postirradiation.
Results showed that γ-radiation reduced cell proliferation, adhesion, spreading, and osteogenic differentiation.
2 Gy radiation promoted adipogenic differentiation, but it was significantly decreased when dosage reached 4 Gy.
In conclusion, results suggest that γ-radiation influenced BMSCs behaviors in a dosage-dependent manner except adipogenic differentiation, low dose promoted it, and high dose inhibited it.
This effect was influenced by surface characteristics, which may explain the different failure rate of various implants in patients after radiation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Huang, Bo& Guang, Mengkai& Ye, Jun& Gong, Ping& Tang, Hua. 2015. Effect of Increasing Doses of γ-Radiation on Bone Marrow Stromal Cells Grown on Smooth and Rough Titanium Surfaces. Stem Cells International،Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1076191
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Huang, Bo…[et al.]. Effect of Increasing Doses of γ-Radiation on Bone Marrow Stromal Cells Grown on Smooth and Rough Titanium Surfaces. Stem Cells International No. 2015 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1076191
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Huang, Bo& Guang, Mengkai& Ye, Jun& Gong, Ping& Tang, Hua. Effect of Increasing Doses of γ-Radiation on Bone Marrow Stromal Cells Grown on Smooth and Rough Titanium Surfaces. Stem Cells International. 2015. Vol. 2015, no. 2015, pp.1-11.
https://search.emarefa.net/detail/BIM-1076191
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1076191
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر