All-Trans Retinoic Acid Improves the Effects of Bone Marrow-Derived Mesenchymal Stem Cells on the Treatment of Ankylosing Spondylitis: An In Vitro Study
المؤلفون المشاركون
Li, Yuxi
Wang, Peng
Xie, Zhongyu
Wu, Yanfeng
Shen, Huiyong
Li, Deng
Wang, Le
Su, Hongjun
Deng, Wen
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-01
دولة النشر
مصر
عدد الصفحات
10
الملخص EN
Previous studies have demonstrated the immunosuppressive effects of both all-trans retinoic acid (ATRA) and mesenchymal stem cells (MSCs).
The present study aimed to assess the immunoregulatory effects of ATRA on MSCs in the treatment of ankylosing spondylitis (AS).
Bone marrow-derived MSCs from healthy donors were pretreated with ATRA and cocultured with CD3/28-activated peripheral blood mononuclear cells (PBMCs) derived from AS patients.
Frequencies of Th17 and regulatory T (Treg) cells were analyzed using flow cytometry.
The secretion and the mRNA level of key cytokines were measured with cytometric bead array and quantitative real-time PCR, respectively.
ATRA pretreatment increased interleukin-6 (IL-6) secretion of MSCs.
Th17 and Treg subset populations were increased and reduced by ATRA-pretreated MSCs, respectively.
ATRA-pretreated MSCs significantly decreased not only the vital pathogenic cytokine in AS, tumor necrosis factor-α (TNF-α), but also AS-boosting factors interleukin-17 (IL-17A) and interferon-γ (IFN-γ).
These results indicated that IL-6 may be a potential protective factor in AS and highlighted the promising role of ATRA in improving the efficacy of MSC-based treatment of AS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Deng& Wang, Peng& Li, Yuxi& Xie, Zhongyu& Wang, Le& Su, Hongjun…[et al.]. 2015. All-Trans Retinoic Acid Improves the Effects of Bone Marrow-Derived Mesenchymal Stem Cells on the Treatment of Ankylosing Spondylitis: An In Vitro Study. Stem Cells International،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1076222
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Deng…[et al.]. All-Trans Retinoic Acid Improves the Effects of Bone Marrow-Derived Mesenchymal Stem Cells on the Treatment of Ankylosing Spondylitis: An In Vitro Study. Stem Cells International No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1076222
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Deng& Wang, Peng& Li, Yuxi& Xie, Zhongyu& Wang, Le& Su, Hongjun…[et al.]. All-Trans Retinoic Acid Improves the Effects of Bone Marrow-Derived Mesenchymal Stem Cells on the Treatment of Ankylosing Spondylitis: An In Vitro Study. Stem Cells International. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1076222
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1076222
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر