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Particle Radiation-Induced Nontargeted Effects in Bone-Marrow-Derived Endothelial Progenitor Cells
المؤلفون المشاركون
Sasi, Sharath P.
Park, Daniel
Muralidharan, Sujatha
Wage, Justin
Kiladjian, Albert
Onufrak, Jillian
Enderling, Heiko
Yan, Xinhua
Goukassian, David A.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-05
دولة النشر
مصر
عدد الصفحات
15
الملخص EN
Bone-marrow- (BM-) derived endothelial progenitor cells (EPCs) are critical for endothelial cell maintenance and repair.
During future space exploration missions astronauts will be exposed to space irradiation (IR) composed of a spectrum of low-fluence protons (1H) and high charge and energy (HZE) nuclei (e.g., iron-56Fe) for extended time.
How the space-type IR affects BM-EPCs is limited.
In media transfer experiments in vitro we studied nontargeted effects induced by 1H- and 56Fe-IR conditioned medium (CM), which showed significant increase in the number of p-H2AX foci in nonirradiated EPCs between 2 and 24 h.
A 2–15-fold increase in the levels of various cytokines and chemokines was observed in both types of IR-CM at 24 h.
Ex vivo analysis of BM-EPCs from single, low-dose, full-body 1H- and 56Fe-IR mice demonstrated a cyclical (early 5–24 h and delayed 28 days) increase in apoptosis.
This early increase in BM-EPC apoptosis may be the effect of direct IR exposure, whereas late increase in apoptosis could be a result of nontargeted effects (NTE) in the cells that were not traversed by IR directly.
Identifying the role of specific cytokines responsible for IR-induced NTE and inhibiting such NTE may prevent long-term and cyclical loss of stem and progenitors cells in the BM milieu.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sasi, Sharath P.& Park, Daniel& Muralidharan, Sujatha& Wage, Justin& Kiladjian, Albert& Onufrak, Jillian…[et al.]. 2015. Particle Radiation-Induced Nontargeted Effects in Bone-Marrow-Derived Endothelial Progenitor Cells. Stem Cells International،Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1076228
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sasi, Sharath P.…[et al.]. Particle Radiation-Induced Nontargeted Effects in Bone-Marrow-Derived Endothelial Progenitor Cells. Stem Cells International No. 2015 (2015), pp.1-15.
https://search.emarefa.net/detail/BIM-1076228
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sasi, Sharath P.& Park, Daniel& Muralidharan, Sujatha& Wage, Justin& Kiladjian, Albert& Onufrak, Jillian…[et al.]. Particle Radiation-Induced Nontargeted Effects in Bone-Marrow-Derived Endothelial Progenitor Cells. Stem Cells International. 2015. Vol. 2015, no. 2015, pp.1-15.
https://search.emarefa.net/detail/BIM-1076228
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1076228
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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