Pretreatment of Adipose Derived Stem Cells with Curcumin Facilitates Myocardial Recovery via Antiapoptosis and Angiogenesis
المؤلفون المشاركون
Liu, Jianfeng
Zhu, Ping
Song, Peng
Xiong, Weiping
Chen, Haixu
Peng, Wenhui
Wang, Shuxia
Li, Shan
Fu, Zhiqing
Wang, Yutang
Wang, Haibin
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-05
دولة النشر
مصر
عدد الصفحات
12
الملخص EN
The poor survival rate of transplanted stem cells in ischemic myocardium has limited their therapeutic efficacy.
Curcumin has potent antioxidant property.
This study investigates whether prior curcumin treatment protects stem cells from oxidative stress injury and improves myocardial recovery following cells transplantation.
Autologous Sprague-Dawley rat adipose derived mesenchymal stem cells (ADSCs) were pretreated with or without curcumin.
The hydrogen peroxide/serum deprivation (H2O2/SD) medium was used to mimic the ischemic condition in vitro.
Cytoprotective effects of curcumin on ADSCs were evaluated.
Curcumin pretreatment significantly increased cell viability and VEGF secretion, and decreased cell injury and apoptosis via regulation of PTEN/Akt/p53 and HO-1 signal proteins expression.
The therapeutic potential of ADSCs implantation was investigated in myocardial ischemia-reperfusion injury (IRI) model.
Transplantation of curcumin pretreated ADSCs not only resulted in better heart function, higher cells retention, and smaller infarct size, but also decreased myocardial apoptosis, promoted neovascularization, and increased VEGF level in ischemic myocardium.
Together, priming of ADSCs with curcumin improved tolerance to oxidative stress injury and resulted in enhancement of their therapeutic potential of ADSCs for myocardial repair.
Curcumin pretreatment is a promising adjuvant strategy for stem cells transplantation in myocardial restoration.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Jianfeng& Zhu, Ping& Song, Peng& Xiong, Weiping& Chen, Haixu& Peng, Wenhui…[et al.]. 2015. Pretreatment of Adipose Derived Stem Cells with Curcumin Facilitates Myocardial Recovery via Antiapoptosis and Angiogenesis. Stem Cells International،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1076308
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Jianfeng…[et al.]. Pretreatment of Adipose Derived Stem Cells with Curcumin Facilitates Myocardial Recovery via Antiapoptosis and Angiogenesis. Stem Cells International No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1076308
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Jianfeng& Zhu, Ping& Song, Peng& Xiong, Weiping& Chen, Haixu& Peng, Wenhui…[et al.]. Pretreatment of Adipose Derived Stem Cells with Curcumin Facilitates Myocardial Recovery via Antiapoptosis and Angiogenesis. Stem Cells International. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1076308
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1076308
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر