Sonic Hedgehog Produced by Bone Marrow-Derived Mesenchymal Stromal Cells Supports Cell Survival in Myelodysplastic Syndrome
المؤلفون المشاركون
Zou, Jixue
Hong, Yan
Tong, Yin
Wei, Ju
Qin, Youwen
Shao, Shan
Wang, Chun
Zhou, Kun
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-03-15
دولة النشر
مصر
عدد الصفحات
13
الملخص EN
The role of marrow microenvironment in the pathogenesis of myelodysplastic syndrome (MDS) remains controversial.
Therefore, we studied the influence of bone marrow-derived mesenchymal stromal cells (BMSCs) from patients with different risk types of MDS on the survival of the MDS cell lines SKM-1 and MUTZ-1.
We first demonstrated that the expression of Sonic hedgehog (Shh), smoothened (Smo), and glioma-associated oncogene homolog 1 (Gli1) was increased in MDS patients n = 23 ; the increase in expression was positively correlated with the presence of high-risk factors.
The Shh signaling inhibitor, cyclopamine, inhibited high-risk MDS BMSC-induced survival of SKM-1 and MUTZ-1 cells, suggesting a role for Shh signaling in MDS cell survival.
Furthermore, cyclopamine-mediated inhibition of Shh signaling in SKM-1 and MUTZ-1 cells resulted in decreased DNMT1 expression and cell survival; however, exogenous Shh peptide had the opposite effect, suggesting that Shh signaling could regulate the expression of DNMT1, thereby modulating cell survival in MDS.
In addition, the apoptosis of SKM-1 and MUTZ-1 cell increased significantly when cultured with cyclopamine and a demethylation agent, 5-Aza-2′-deoxycytidine.
These findings suggest that Shh signaling from BMSCs is important in the pathogenesis of MDS and could play a role in disease progression by modulating methylation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zou, Jixue& Hong, Yan& Tong, Yin& Wei, Ju& Qin, Youwen& Shao, Shan…[et al.]. 2015. Sonic Hedgehog Produced by Bone Marrow-Derived Mesenchymal Stromal Cells Supports Cell Survival in Myelodysplastic Syndrome. Stem Cells International،Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1076394
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zou, Jixue…[et al.]. Sonic Hedgehog Produced by Bone Marrow-Derived Mesenchymal Stromal Cells Supports Cell Survival in Myelodysplastic Syndrome. Stem Cells International No. 2015 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1076394
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zou, Jixue& Hong, Yan& Tong, Yin& Wei, Ju& Qin, Youwen& Shao, Shan…[et al.]. Sonic Hedgehog Produced by Bone Marrow-Derived Mesenchymal Stromal Cells Supports Cell Survival in Myelodysplastic Syndrome. Stem Cells International. 2015. Vol. 2015, no. 2015, pp.1-13.
https://search.emarefa.net/detail/BIM-1076394
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1076394
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر