Nitric Oxide Bioavailability in Obstructive Sleep Apnea: Interplay of Asymmetric Dimethylarginine and Free Radicals

المؤلفون المشاركون

Badran, Mohammad
Ayas, Najib
Golbidi, Saeid
Laher, Ismail

المصدر

Sleep Disorders

العدد

المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2015-05-06

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الأمراض

الملخص EN

Obstructive sleep apnea (OSA) occurs in 2% of middle-aged women and 4% of middle-aged men and is considered an independent risk factor for cerebrovascular and cardiovascular diseases.

Nitric oxide (NO) is an important endothelium derived vasodilating substance that plays a critical role in maintaining vascular homeostasis.

Low levels of NO are associated with impaired endothelial function.

Asymmetric dimethylarginine (ADMA), an analogue of L-arginine, is a naturally occurring product of metabolism found in the human circulation.

Elevated levels of ADMA inhibit NO synthesis while oxidative stress decreases its bioavailability, so impairing endothelial function and promoting atherosclerosis.

Several clinical trials report increased oxidative stress and ADMA levels in patients with OSA.

This review discusses the role of oxidative stress and increased ADMA levels in cardiovascular disease resulting from OSA.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Badran, Mohammad& Golbidi, Saeid& Ayas, Najib& Laher, Ismail. 2015. Nitric Oxide Bioavailability in Obstructive Sleep Apnea: Interplay of Asymmetric Dimethylarginine and Free Radicals. Sleep Disorders،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1076487

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Badran, Mohammad…[et al.]. Nitric Oxide Bioavailability in Obstructive Sleep Apnea: Interplay of Asymmetric Dimethylarginine and Free Radicals. Sleep Disorders No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1076487

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Badran, Mohammad& Golbidi, Saeid& Ayas, Najib& Laher, Ismail. Nitric Oxide Bioavailability in Obstructive Sleep Apnea: Interplay of Asymmetric Dimethylarginine and Free Radicals. Sleep Disorders. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1076487

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1076487