Beneficial effect of flaxseed and flaxseed oil by adjusting omega6: omega3 ratio on lipid metabolism in high cholesterol diet fed rats
العناوين الأخرى
التأثير المفيد لزيت الكتان و بذور الكتان عن طريق ضبط نسبة أوميجا ٦: أوميغا ٣ على التمثيل الغذائي للدهون في الفئران التي تغذى على نسبة عالية من الكوليسترول
المؤلفون المشاركون
Muhammad, Suhayr Fawzi
Naji, Halah Mahmud
Murad, Rasha Midhat
المصدر
Research Journal Specific Education
العدد
المجلد 2020، العدد 58 (30 إبريل/نيسان 2020)، ص ص. 117-142، 26ص.
الناشر
جامعة المنصورة كلية التربية النوعية
تاريخ النشر
2020-04-30
دولة النشر
مصر
عدد الصفحات
26
التخصصات الرئيسية
الموضوعات
- الجهاز القلبي الوعائي
- الأوعية الدموية
- الزيوت النباتية
- البذور
- الأمراض
- الأمراض المزمنة
- أمراض القلب التاجية
- التهاب المفاصل الروماتويدي
- الكتان
- فرط كوليسترول الدم
الملخص EN
Hypercholesterolemia is one of the major risk factors that precipitate coronary heart disease and atherosclerosis.
abnormal lipid metabolism is a main cause of dyslipidemia, which is a major risk factor for cardiovascular disease, obesity, cholestasis, and overall mortality.
It is well known that diet plays an important role in the control of cholesterol homeostasis.
Many studies reported that flaxseed may have protective effect against diseases like cardiovascular diseases CVD, reducing the risk of cancers, reducing the incident and progress of diabetes.
High omega-6/omega-3 ratio intake promotes development of many chronic diseases like cardiovascular disease, cancer, inflammatory and autoimoune disease, rheumatoid arthritis, asthma.
Accordingly, the purpose of the present study was to investigate the effect of flaxseed and flaxseed oil against high cholesterol diet induced hypercholesterolemia in rats by adjusting ω6: ω3ratio(2.5: 1), .
Also, to determine whether flaxseed or flaxseed oil when administered to hypercholesterolemic induced-rats beneficial for treatment of hypercholesterolemia complications.
Animals(40 rats) were divided randomly into 4 equal groups.
G1 fed on basal diet (NC), G2 fed on HFD only(PC).
G3 and G4 fed on HFD with adjust ω6: ω3 ratio(2.5: 1) by either flaxseed oil (FSO) or flaxseed( FS).
Blood samples were collected every 3 weeks for lipid parameters monitoring (serum total cholesterol (TC), triglycerides (TG).
high density lipoprotein cholesterol (HDL) whereas low density lipoprotein cholesterol (LDL) was calculated.
All samples (heart, kidney, spleen, lungs and brain, and liver) of each animal were weighted.
liver and kidney were kept in formalin solution (10% ) for the histopathological investigationResults showed that ω6: ω3 ratio was 1: 3.8 in FS and 1: 4.2 in FSO, while such ratio was 10: 1 in grease.
The results showed that adjusting ω6: ω3 ratio by FS or FSO led to significant high decrease of plasma cholesterol, triglyceride, LDL and to increase in HDL after 6 weeks.
Results also indicated that the balance ratio of ω6: ω3 led to decrease in weight of rats as such ratio is important for health and in the prevention and management of obesity.
Histopathology examination of the organs tissue was in parallel with the biochemical results, as liver weight was higher in PC with a marked deterioration in liver tissue while treated groups showed alleviated histopathological alterations.
Moreover, kidney tissues in treated group showed apparently normal glomeruli and tubular epithelium, similar to the negative control group.
These results suggest that, flaxseed oil may be effective in controlling cholesterolemic status and improving dyslipidemia and has the potential in reducing cardiovascular complications due to hypercholesterolemia.
Key words: Omega6, Omega3, lipid profile, Liver, Hypercholesterolemia, high cholesterol diet, rats weight, Flaxseed oil; , Flaxseed
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Muhammad, Suhayr Fawzi& Naji, Halah Mahmud& Murad, Rasha Midhat. 2020. Beneficial effect of flaxseed and flaxseed oil by adjusting omega6: omega3 ratio on lipid metabolism in high cholesterol diet fed rats. Research Journal Specific Education،Vol. 2020, no. 58, pp.117-142.
https://search.emarefa.net/detail/BIM-1076660
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Muhammad, Suhayr Fawzi…[et al.]. Beneficial effect of flaxseed and flaxseed oil by adjusting omega6: omega3 ratio on lipid metabolism in high cholesterol diet fed rats. Research Journal Specific Education No. 58 (Apr. 2020), pp.117-142.
https://search.emarefa.net/detail/BIM-1076660
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Muhammad, Suhayr Fawzi& Naji, Halah Mahmud& Murad, Rasha Midhat. Beneficial effect of flaxseed and flaxseed oil by adjusting omega6: omega3 ratio on lipid metabolism in high cholesterol diet fed rats. Research Journal Specific Education. 2020. Vol. 2020, no. 58, pp.117-142.
https://search.emarefa.net/detail/BIM-1076660
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
-
رقم السجل
BIM-1076660
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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