In-vitro evaluation of the particle size distribution from salbutamol metered dose inhalers
المؤلف
المصدر
Journal of the Royal Medical Services
العدد
المجلد 12، العدد 1 (30 يونيو/حزيران 2005)، ص ص. 71-78، 8ص.
الناشر
الخدمات الطبية الملكية الأردنية
تاريخ النشر
2005-06-30
دولة النشر
الأردن
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective: To evaluate the aerodynamic particle size distribution of salbutamol metered dose inhalers (lOOug per dose) using a modified Multi Stage Liquid Impinger; an impaction method used for measuring particle size distribution, and to assess the effect of the number of puffs sampled on the particle size distribution. Methods: The instrument used for the determination of the aerodynamic particle size distribution was an Astra Draco modified multistage liquid impinger (Copley Instrument, Nottingham UK) The device consists of a throat and five impaction stages.
Using a flow rate of 60 liters per minute, the effective cut - off diameters of stages 1, 2, 3 and 4 are 13.0, 6.8, 3.1 and 1.7 jxm respectively.
The fifth and final stage comprises an integral filter to capture the fraction of particles with a size less than 1.7 um.
A high-pressure liquid chromatographic method was adapted for the analysis of salbutamol. Results: The Mass Median Aerodynamic Diameter was determined for 2, 5, 10, 20, and 40 consecutive actuations using the modified Multi Stage Liquid Impinger.
The mean ± (SD) Mass Median Aerodynamic Diameter was 2.31± (0.06), 2.09 ± (0.06), 2.15 ± (0.05), 2.28 ± (0.02) and 2.10 ± (0.07)um respectively.
The geometric standard deviation values for 2, 5, 10, 20 and 40 doses were 1.40, 1.50, 1.43, 1.35 and 1.46 respectively.
The mean ± (SD) fine particle dose values for 2, 5, 10, 20 and 40 doses were 48.02 ± (2.53), 41.94± (3.05), 47.12 ± (2.89), 54.61± (1.43) and 52.7 ± (2.09) respectively. Conclusion: The results in this study showed differences between aerodynamic particle size distributions when a different number of doses were used. The Mass Median Aerodynamic Diameter increased as the number of doses increased from five to twenty doses, while the results showed violation at two and forty doses, this could be due to a number of factors such as: Inadequate extraction of the drug from the different stages of the Multi Stage Liquid Impinger, or problems in the HPLC analysis. Key words: Salbutamol; Metered Dose Inhalers; Particle Size Distribution; Mass Median Aerodynamic Diameter, Multi Stage Liquid Impinger.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Shawish, Husayn A.. 2005. In-vitro evaluation of the particle size distribution from salbutamol metered dose inhalers. Journal of the Royal Medical Services،Vol. 12, no. 1, pp.71-78.
https://search.emarefa.net/detail/BIM-107752
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Shawish, Husayn A.. In-vitro evaluation of the particle size distribution from salbutamol metered dose inhalers. Journal of the Royal Medical Services Vol. 12, no. 1 (Jun. 2005), pp.71-78.
https://search.emarefa.net/detail/BIM-107752
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Shawish, Husayn A.. In-vitro evaluation of the particle size distribution from salbutamol metered dose inhalers. Journal of the Royal Medical Services. 2005. Vol. 12, no. 1, pp.71-78.
https://search.emarefa.net/detail/BIM-107752
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 77-78
رقم السجل
BIM-107752
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر