![](/images/graphics-bg.png)
Downregulation of S100 Calcium Binding Protein A9 in Esophageal Squamous Cell Carcinoma
المؤلفون المشاركون
Pandey, Akhilesh
Sathe, Gajanan J.
Sirdeshmukh, Ravi
Pawar, Harsh
Srikanth, Srinivas M.
Kashyap, Manoj Kumar
Chavan, Sandip
Singal, Mukul
Manju, H. C.
Kumar, Kariyanakatte Veeraiah Veerendra
Vijayakumar, M.
Kumar, Rekha V.
Prasad, T. S. Keshava
Harsha, H. C.
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-14
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
The development of esophageal squamous cell carcinoma (ESCC) is poorly understood and the major regulatory molecules involved in the process of tumorigenesis have not yet been identified.
We had previously employed a quantitative proteomic approach to identify differentially expressed proteins in ESCC tumors.
A total of 238 differentially expressed proteins were identified in that study including S100 calcium binding protein A9 (S100A9) as one of the major downregulated proteins.
In the present study, we carried out immunohistochemical validation of S100A9 in a large cohort of ESCC patients to determine the expression and subcellular localization of S100A9 in tumors and adjacent normal esophageal epithelia.
Downregulation of S100A9 was observed in 67% ( n = 192 ) of 288 different ESCC tumors, with the most dramatic downregulation observed in the poorly differentiated tumors (99/111).
Expression of S100A9 was restricted to the prickle and functional layers of normal esophageal mucosa and localized predominantly in the cytoplasm and nucleus whereas virtually no expression was observed in the tumor and stromal cells.
This suggests the important role that S100A9 plays in maintaining the differentiated state of epithelium and suggests that its downregulation may be associated with increased susceptibility to tumor formation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pawar, Harsh& Srikanth, Srinivas M.& Kashyap, Manoj Kumar& Sathe, Gajanan J.& Chavan, Sandip& Singal, Mukul…[et al.]. 2015. Downregulation of S100 Calcium Binding Protein A9 in Esophageal Squamous Cell Carcinoma. The Scientific World Journal،Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1078673
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pawar, Harsh…[et al.]. Downregulation of S100 Calcium Binding Protein A9 in Esophageal Squamous Cell Carcinoma. The Scientific World Journal No. 2015 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1078673
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pawar, Harsh& Srikanth, Srinivas M.& Kashyap, Manoj Kumar& Sathe, Gajanan J.& Chavan, Sandip& Singal, Mukul…[et al.]. Downregulation of S100 Calcium Binding Protein A9 in Esophageal Squamous Cell Carcinoma. The Scientific World Journal. 2015. Vol. 2015, no. 2015, pp.1-10.
https://search.emarefa.net/detail/BIM-1078673
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1078673
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)