Comment on “Sodium Bicarbonate Therapy in Patients with Metabolic Acidosis”
المؤلف
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-2، 2ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-06-02
دولة النشر
مصر
عدد الصفحات
2
التخصصات الرئيسية
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
In the paper of Adeva-Andany et al.
[1] there are some discrepancies with the literature.(1)The authors write “Evidence that significant harmful effects are derived from metabolic acidosis by itself has not been provided in human beings and therefore the successful management of metabolic acidosis require the therapy of the underlying causative disorder.” According to Edge et al.
[2] and Nyenwe et al.
[3] metabolic acidosis (= low blood-pH = high concentration of hydrogen ions H+) is the immediate cause of decreased level of consciousness including coma: the glycolytic enzyme phosphofructokinase is pH-dependent, as its activity is decreasing with decreasing pH.
The consequence is impaired utilisation of glucose in brain cells.
Where are published papers denying the results of Edge et al.
and Nyenwe et al.?(2)The authors write “Both retrospective and prospective studies have consistently documented that sodium bicarbonate therapy does not improve metabolic responses, biochemical parameters, acid-base balance normalisation, or clinical outcomes among patients with DKA, either children or adults.” In diabetic ketoacidosis, life-threatening is only its most severe stage, coma.
If the facts presented in paragraph 1 are correct, thus increase of the very low blood-pH in the comatose patient after infusion of alkalising solution (such as sodium bicarbonate) should result in recovery to normal state of consciousness.
And this has been reported in reality: lethality of coma in diabetic ketoacidosis is zero with treatment which includes infusions of alkalising solutions, for example, Umpierrez et al.
[4].
Without alkalising solutions, lethality of coma in diabetic ketoacidosis is up to 100%, for example, Basu et al.
[5].
Where are published reports on zero lethality of coma in diabetic ketoacidosis without infusions of alkalising solutions?
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rosival, Viktor. 2015. Comment on “Sodium Bicarbonate Therapy in Patients with Metabolic Acidosis”. The Scientific World Journal،Vol. 2015, no. 2015, pp.1-2.
https://search.emarefa.net/detail/BIM-1079266
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rosival, Viktor. Comment on “Sodium Bicarbonate Therapy in Patients with Metabolic Acidosis”. The Scientific World Journal No. 2015 (2015), pp.1-2.
https://search.emarefa.net/detail/BIM-1079266
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rosival, Viktor. Comment on “Sodium Bicarbonate Therapy in Patients with Metabolic Acidosis”. The Scientific World Journal. 2015. Vol. 2015, no. 2015, pp.1-2.
https://search.emarefa.net/detail/BIM-1079266
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1079266
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر