Subacute Toxicity Profile of Lacidipine Nanoformulation in Wistar Rats
المؤلفون المشاركون
Mutalik, Srinivas
Shirodkar, Rupesh
Misra, Chandrasekhar
GH, Chethan
Shetty, Pallavi
Attari, Zenab
Lewis, Shaila
المصدر
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-05-25
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الطب البشري
تكنولوجيا المعلومات وعلم الحاسوب
الملخص EN
The present study was aimed at investigating the safety of Lacidipine (LCDP) loaded nanostructured lipid carriers (NLCs) in Wistar rats.
NLCs were formulated using ultrasound dispersion technique.
Animals were orally treated once daily with NLCs containing 0.140 mg, 0.350 mg, and 0.875 mg of LCDP as low, medium, and high dose per kg body weight, respectively, during 28 days along with blank formulation and pure LCDP.
Control rats were fed with water.
Animals were observed throughout experiment period and their body weight was recorded once weekly.
Overnight fasted rats were sacrificed on the 29th day.
Study revealed no signs or symptoms of toxicity or morbidity.
No significant changes in the body weight were observed between treated and control group.
Significant increase in left testis weight and liver weight was observed in male and female rats, respectively.
Haematological estimation revealed significant decrease in haemoglobin count in male rats while female rats showed significant increase in granulocyte count.
All the serum clinical parameters were within the normal range and no gross histopathological changes were observed.
No delayed effect was noted in satellite group.
The results indicate that developed LCDP loaded NLCs are safe when administered orally in rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shirodkar, Rupesh& Misra, Chandrasekhar& GH, Chethan& Shetty, Pallavi& Attari, Zenab& Mutalik, Srinivas…[et al.]. 2015. Subacute Toxicity Profile of Lacidipine Nanoformulation in Wistar Rats. The Scientific World Journal،Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1079315
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shirodkar, Rupesh…[et al.]. Subacute Toxicity Profile of Lacidipine Nanoformulation in Wistar Rats. The Scientific World Journal No. 2015 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1079315
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shirodkar, Rupesh& Misra, Chandrasekhar& GH, Chethan& Shetty, Pallavi& Attari, Zenab& Mutalik, Srinivas…[et al.]. Subacute Toxicity Profile of Lacidipine Nanoformulation in Wistar Rats. The Scientific World Journal. 2015. Vol. 2015, no. 2015, pp.1-12.
https://search.emarefa.net/detail/BIM-1079315
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1079315
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر