Royal Jelly and Its Dual Role in TNBS Colitis in Mice

الملخص EN

Royal Jelly (RJ) is widely consumed in diets throughout the world due to its beneficial effects: antioxidant, antitumor and anti-inflammatory.

We have investigated the role of RJ in the development of TNBS colitis in mice.

Colitis was induced by a rectal instillation of TNBS at 0.1 mL per mouse.

Intestine samples of the animals orally treated with RJ (100, 150, and 200 mg/kg) were collected for antioxidant assays (GSH and GSH-Px), proinflammatory protein quantification (COX-2 and NF-κB), and histological analyses.

RJ 100 mg/kg maintained GSH levels and increased the activity of GSH-Px, downregulated key inflammatory mediators (COX-2 and NF-κB), and decreased the lesions caused by TNBS as shown by the histological analyses.

In conclusion, RJ showed anti-inflammatory and antioxidant properties in experimental colitis, resulting in the amelioration of the macroscopic and histological analyses.

These results corroborate with the RJ supplementation in diets.