Systemic Candida parapsilosis Infection Model in Immunosuppressed ICR Mice and Assessing the Antifungal Efficiency of Fluconazole
المؤلفون المشاركون
Zhang, Yu
Wu, Yu’e
Min, Fangui
Pan, Jinchun
Wang, Jing
Yuan, Wen
Huang, Ren
Zhang, Lixin
المصدر
Veterinary Medicine International
العدد
المجلد 2015، العدد 2015 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-07-09
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
This study was to establish a systemic C.
parapsilosis infection model in immunosuppressed ICR mice induced by cyclophosphamide and evaluate the antifungal efficiency of fluconazole.
Three experiments were set to confirm the optimal infectious dose of C.
parapsilosis, outcomes of infectious model, and antifungal efficiency of fluconazole in vivo, respectively.
In the first experiment, comparisons of survival proportions between different infectious doses treated groups showed that the optimal inoculum for C.
parapsilosis was 0.9 × 105 CFU per mouse.
The following experiment was set to observe the outcomes of infection at a dose of 0.9 × 105 CFU C.
parapsilosis.
Postmortem and histopathological examinations presented fugal-specific lesions in multiorgans, especially in kidneys, characterized by inflammation, numerous microabscesses, and fungal infiltration.
The CFU counts were consistent with the histopathological changes in tissues.
Th1/Th2 cytokine imbalance was observed with increases of proinflammatory cytokines and no responses of anti-inflammatory cytokines in sera and kidneys.
In the last experiment, model based evaluation of fluconazole indicated that there were ideal antifungal activities for fluconazole at dosages of 10–50 mg/kg/d.
Data demonstrates that the research team has established a systemic C.
parapsilosis infection model in immunosuppressed ICR mice, affording opportunities for increasing our understanding of fungal pathogenesis and treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Yu’e& Min, Fangui& Pan, Jinchun& Wang, Jing& Yuan, Wen& Zhang, Yu…[et al.]. 2015. Systemic Candida parapsilosis Infection Model in Immunosuppressed ICR Mice and Assessing the Antifungal Efficiency of Fluconazole. Veterinary Medicine International،Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1079382
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Yu’e…[et al.]. Systemic Candida parapsilosis Infection Model in Immunosuppressed ICR Mice and Assessing the Antifungal Efficiency of Fluconazole. Veterinary Medicine International No. 2015 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1079382
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Yu’e& Min, Fangui& Pan, Jinchun& Wang, Jing& Yuan, Wen& Zhang, Yu…[et al.]. Systemic Candida parapsilosis Infection Model in Immunosuppressed ICR Mice and Assessing the Antifungal Efficiency of Fluconazole. Veterinary Medicine International. 2015. Vol. 2015, no. 2015, pp.1-7.
https://search.emarefa.net/detail/BIM-1079382
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1079382
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر