Evaluation of serum C24 ceramide as a predictor of hepatic decompensation in patients with liver cirrhosis
المؤلفون المشاركون
Atiyyah, Fawzi
Abd al-Munim, Amirah
Khalil, Khalil A.
Abd al-Fattah, Muhammad
المصدر
Suez Canal University Medical Journal
العدد
المجلد 23، العدد 2 (31 ديسمبر/كانون الأول 2020)، ص ص. 214-220، 7ص.
الناشر
تاريخ النشر
2020-12-31
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: It was found that there is a significant progressive decrease in the serum level of C24 ceramide with increasing severity of cirrhosis.
Our aim was to evaluate the efficacy of C24 Ceramide (C24Cer) as a predictor of decompensation in cirrhotic patients at Suez Canal University hospital, Ismailia, Egypt.
Subjects and Methods: Patients with viral related liver cirrhosis were consecutively confronted in the outpatient and inpatient sections.
They were classified according to Child-Pugh into A, B, C groups.
A control group (13 individuals) was compared with each group.
Clinical assessment and Liver profile were performed.
The serum level of C24Cer was measured using 20μL extracted serum with methanol: chloroform: HCl (15: 83: 2), using liquid chromatography coupled to tandem mass spectrometry.
Results: Patients with Child-A cirrhosis showed a significantly higher mean C24Cer level compared to Child-C patients (p <0.001).
Pairwise comparisons showed a statistically significant stepwise decrease in the mean C24Cer level from control group to Child-A, B then C cirrhotic patients respectively (p-value: 0.029, <0.001, and <0.001).
There was a highly significant negative correlation between C24Cer and each of total bilirubin, PT, ascites grade, hepatic encephalopathy grade, and Child score (p < 0.001 for each) as well as a highly significant positive correlation with albumin level (p < 0.001).
Conclusion: a low serum C24Cer is associated with hepatic decompensation and is good with a sensitivity of 100% and a specificity of 73% .
Further studies are needed to elucidate the real-life significance of C24Cer as a non-invasive mortality predictor in cirrhosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Atiyyah, Fawzi& Khalil, Khalil A.& Abd al-Munim, Amirah& Abd al-Fattah, Muhammad. 2020. Evaluation of serum C24 ceramide as a predictor of hepatic decompensation in patients with liver cirrhosis. Suez Canal University Medical Journal،Vol. 23, no. 2, pp.214-220.
https://search.emarefa.net/detail/BIM-1084676
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Atiyyah, Fawzi…[et al.]. Evaluation of serum C24 ceramide as a predictor of hepatic decompensation in patients with liver cirrhosis. Suez Canal University Medical Journal Vol. 23, no. 2 (2020), pp.214-220.
https://search.emarefa.net/detail/BIM-1084676
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Atiyyah, Fawzi& Khalil, Khalil A.& Abd al-Munim, Amirah& Abd al-Fattah, Muhammad. Evaluation of serum C24 ceramide as a predictor of hepatic decompensation in patients with liver cirrhosis. Suez Canal University Medical Journal. 2020. Vol. 23, no. 2, pp.214-220.
https://search.emarefa.net/detail/BIM-1084676
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 220
رقم السجل
BIM-1084676
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر