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Evaluation of serum C24 ceramide as a predictor of hepatic decompensation in patients with liver cirrhosis
المؤلفون المشاركون
Atiyyah, Fawzi
Abd al-Munim, Amirah
Khalil, Khalil A.
Abd al-Fattah, Muhammad
المصدر
Suez Canal University Medical Journal
العدد
المجلد 23، العدد 2 (31 ديسمبر/كانون الأول 2020)، ص ص. 214-220، 7ص.
الناشر
تاريخ النشر
2020-12-31
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: It was found that there is a significant progressive decrease in the serum level of C24 ceramide with increasing severity of cirrhosis.
Our aim was to evaluate the efficacy of C24 Ceramide (C24Cer) as a predictor of decompensation in cirrhotic patients at Suez Canal University hospital, Ismailia, Egypt.
Subjects and Methods: Patients with viral related liver cirrhosis were consecutively confronted in the outpatient and inpatient sections.
They were classified according to Child-Pugh into A, B, C groups.
A control group (13 individuals) was compared with each group.
Clinical assessment and Liver profile were performed.
The serum level of C24Cer was measured using 20μL extracted serum with methanol: chloroform: HCl (15: 83: 2), using liquid chromatography coupled to tandem mass spectrometry.
Results: Patients with Child-A cirrhosis showed a significantly higher mean C24Cer level compared to Child-C patients (p <0.001).
Pairwise comparisons showed a statistically significant stepwise decrease in the mean C24Cer level from control group to Child-A, B then C cirrhotic patients respectively (p-value: 0.029, <0.001, and <0.001).
There was a highly significant negative correlation between C24Cer and each of total bilirubin, PT, ascites grade, hepatic encephalopathy grade, and Child score (p < 0.001 for each) as well as a highly significant positive correlation with albumin level (p < 0.001).
Conclusion: a low serum C24Cer is associated with hepatic decompensation and is good with a sensitivity of 100% and a specificity of 73% .
Further studies are needed to elucidate the real-life significance of C24Cer as a non-invasive mortality predictor in cirrhosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Atiyyah, Fawzi& Khalil, Khalil A.& Abd al-Munim, Amirah& Abd al-Fattah, Muhammad. 2020. Evaluation of serum C24 ceramide as a predictor of hepatic decompensation in patients with liver cirrhosis. Suez Canal University Medical Journal،Vol. 23, no. 2, pp.214-220.
https://search.emarefa.net/detail/BIM-1084676
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Atiyyah, Fawzi…[et al.]. Evaluation of serum C24 ceramide as a predictor of hepatic decompensation in patients with liver cirrhosis. Suez Canal University Medical Journal Vol. 23, no. 2 (2020), pp.214-220.
https://search.emarefa.net/detail/BIM-1084676
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Atiyyah, Fawzi& Khalil, Khalil A.& Abd al-Munim, Amirah& Abd al-Fattah, Muhammad. Evaluation of serum C24 ceramide as a predictor of hepatic decompensation in patients with liver cirrhosis. Suez Canal University Medical Journal. 2020. Vol. 23, no. 2, pp.214-220.
https://search.emarefa.net/detail/BIM-1084676
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 220
رقم السجل
BIM-1084676
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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