Synergistic effect of tea tree oil on fungi causing vaginal thrush in pregnant women
العناوين الأخرى
التأثير التآزري لزيت شجرة الشاي على الفطريات المسببة لمرض بالسلاق المهبلي عند النساء الحوامل
المؤلفون المشاركون
Dhib, Batul Umran
Dahham, Maryam Tariq
Umar, Abd al-Karim Fattah
المصدر
Journal of Biotechnology Research Center
العدد
المجلد 13، العدد 2 (31 ديسمبر/كانون الأول 2019)، ص ص. 35-44، 10ص.
الناشر
جامعة النهرين مركز بحوث التقنيات الإحيائية
تاريخ النشر
2019-12-31
دولة النشر
العراق
عدد الصفحات
10
التخصصات الرئيسية
الموضوعات
- المرأة الحامل
- المهبل
- المواد الكيميائية
- الزيوت العطرية
- التركيز المثبط الأدنى
- مواد مضادة للفطريات
- داء المبيضات
- موت الخلية
الملخص EN
Background: Vulvovaginal candidiasis(VVC), or Vaginal thrush, is a vaginitis caused by the overgrowth of some opportunistic yeasts of the genus Candida spp.
Australian Tea Tree Oil (TTO) is one of the most important essential oils that contain many compounds that are effective against many bacteria and fungi, which may match the effect of common antibiotics.
Objective: The aim of this study was to isolate and diagnose fungi that causing vaginal thrush, in pregnant women and to study the effect of (pregnancy and pregnancy sequence and age) on the rate of infection compared to non-pregnant, as well as to study the drug sensitivity of isolates towards a number of antifungal and compared that with the inhibitory effectiveness of tea tree oil.
Material and Methods: 75 vaginal swfrom pregnant women and 50 from non-pregnant women were collected at ages ranging from 17-65 years.
The isolates were diagnosed using several methods, including the Vitek2 Compact system.
17 isolates were selected to study the inhibitory effect of ten antifungal agents, six of them were automatically tested by the Vitek 2 compact system, which contains a sensitivity test kit (AST-YS07 Card).
The essential oil (TTO) was analyzed by GC-MS to detect its content of active compounds.
The inhibitory effect of TTO was studied according to "Broth dilution" method to determine minimum inhibitory concentration (MIC) for it, the inhibitory effect of four concentrations of TTO (100% , 50% , 25% , 12.5 % ) was also tested according to "well diffusion" method.
This investigation also included a study of the mechanism of action (TTO).
RESULTS: The rate of infection among pregnant women was (41% ) with the highest rate of infection during the third trimester of pregnancy, while the percentage of non-pregnant women was only 8% .
Vaginal infection was also prevalent in the age group ranged between (17-29 years).
The isolates showed resistance to (Ketoconazol, Terbinafine) while they were sensitive to (Nystatin, clotrimazol), as well as sensitive to all antifungal of (AST-YS07 Card).
The analysis of the TTO using chromatogram showed that it contains 32 chemical compounds, most of them are monoterpene like (Terpinen-4-ol, 1, 8-Cineol).
The MIC of TTO ranged between (4 - < 2 µl/ ml).
The function of TTO is to destroy the structural structure of the cell membrane and change its permeability, thereby leakage of cellular components and cell death.
Conclusion: Pregnancy increases the rate of vaginal candidiasis in women, especially during the third trimester.
TTO is highly effective in inhibiting the growth of opportunistic candida yeasts.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dahham, Maryam Tariq& Umar, Abd al-Karim Fattah& Dhib, Batul Umran. 2019. Synergistic effect of tea tree oil on fungi causing vaginal thrush in pregnant women. Journal of Biotechnology Research Center،Vol. 13, no. 2, pp.35-44.
https://search.emarefa.net/detail/BIM-1093931
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dahham, Maryam Tariq…[et al.]. Synergistic effect of tea tree oil on fungi causing vaginal thrush in pregnant women. Journal of Biotechnology Research Center Vol. 13, no. 2 (2019), pp.35-44.
https://search.emarefa.net/detail/BIM-1093931
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dahham, Maryam Tariq& Umar, Abd al-Karim Fattah& Dhib, Batul Umran. Synergistic effect of tea tree oil on fungi causing vaginal thrush in pregnant women. Journal of Biotechnology Research Center. 2019. Vol. 13, no. 2, pp.35-44.
https://search.emarefa.net/detail/BIM-1093931
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
-
رقم السجل
BIM-1093931
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر