GAKG-RGEKG an Epitope That Provokes Immune Cross-Reactivity between Prevotella sp. and Human Collagen: Evidence of Molecular Mimicry in Chronic Periodontitis
المؤلف
Obando-Pereda, Gustavo Alberto
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-25
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Periodontal disease afflicts 20% of world population.
This process usually occurs in the form of being lethargic and chronic, and consequently this disease is known as chronic process.
All chronic diseases constantly cause activation of the immune system, and therefore the presentation of microbial peptides which are presented to lymphocytes by professional antigen presenting cells can present microbial peptides very similar to important structures of human economy causing autoimmune diseases, process known as molecular mimicry.
Thus, the aim of this study was to verify the presence of molecular mimicry phenomenon between periodontopathogens and human proteins.
Blasting microbes of Socransky periodontal complexes against human collagen were performed and then the proteins with similarities were modelled and were screened in the MHI binding virtual methods.
The epitopes selected were produced and plasma of chronic periodontal volunteers was obtained and a dot immunobinding assay was performed.
Hypothetical protein of Prevotella sp.
and human collagen epitopes with high similarities were positive for dot immunobinding assay.
With this result it can be suggested that the mimicry phenomena can occur on periodontal disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Obando-Pereda, Gustavo Alberto. 2016. GAKG-RGEKG an Epitope That Provokes Immune Cross-Reactivity between Prevotella sp. and Human Collagen: Evidence of Molecular Mimicry in Chronic Periodontitis. Autoimmune Diseases،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1094983
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Obando-Pereda, Gustavo Alberto. GAKG-RGEKG an Epitope That Provokes Immune Cross-Reactivity between Prevotella sp. and Human Collagen: Evidence of Molecular Mimicry in Chronic Periodontitis. Autoimmune Diseases No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1094983
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Obando-Pereda, Gustavo Alberto. GAKG-RGEKG an Epitope That Provokes Immune Cross-Reactivity between Prevotella sp. and Human Collagen: Evidence of Molecular Mimicry in Chronic Periodontitis. Autoimmune Diseases. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1094983
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1094983
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر