Infiltrating CD16+ Are Associated with a Reduction in Peripheral CD14+CD16++ Monocytes and Severe Forms of Lupus Nephritis
المؤلفون المشاركون
Vasquez, Gloria
Burbano, Catalina
Rojas, Mauricio
Barrera García, Anabel
Gómez-Puerta, José A.
Arias, Luis F.
Restrepo, Mauricio
Vanegas, Adriana L.
Muñoz, Carlos H.
González, Luis A.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-13
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Our aim was to characterize glomerular monocytes (Mo) infiltration and to correlate them with peripheral circulating Mo subsets and severity of lupus nephritis (LN).
Methods.
We evaluated 48 LN biopsy samples from a referral hospital.
Recognition of Mo cells was done using microscopic view and immunohistochemistry stain with CD14 and CD16.
Based on the number of cells, we classified LN samples as low degree of diffuse infiltration (<5 cells) and high degree of diffuse infiltration (≥5 cells).
Immunophenotyping of peripheral Mo subsets was done using flow cytometry.
Results.
Mean age was 34.0±11.7 years and the mean SLEDAI was 17.5±6.9.
The most common SLE manifestations were proteinuria (91%) and hypocomplementemia (75%).
Severe LN was found in 70% of patients (Class III, 27%; Class IV, 43%).
Severe LN patients and patients with higher grade of CD16+ infiltration had lower levels of nonclassical (CD14+CD16++) Mo in peripheral blood.
Conclusions.
Our results might suggest that those patients with more severe forms of LN had a higher grade of CD14+CD16+ infiltration and lower peripheral levels of nonclassical (CD14+CD16++) Mo and might reflect a recruitment process in renal tissues.
However, given the small sample, our results must be interpreted carefully.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Barrera García, Anabel& Gómez-Puerta, José A.& Arias, Luis F.& Burbano, Catalina& Restrepo, Mauricio& Vanegas, Adriana L.…[et al.]. 2016. Infiltrating CD16+ Are Associated with a Reduction in Peripheral CD14+CD16++ Monocytes and Severe Forms of Lupus Nephritis. Autoimmune Diseases،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1094990
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Barrera García, Anabel…[et al.]. Infiltrating CD16+ Are Associated with a Reduction in Peripheral CD14+CD16++ Monocytes and Severe Forms of Lupus Nephritis. Autoimmune Diseases No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1094990
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Barrera García, Anabel& Gómez-Puerta, José A.& Arias, Luis F.& Burbano, Catalina& Restrepo, Mauricio& Vanegas, Adriana L.…[et al.]. Infiltrating CD16+ Are Associated with a Reduction in Peripheral CD14+CD16++ Monocytes and Severe Forms of Lupus Nephritis. Autoimmune Diseases. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1094990
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1094990
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر