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Thymoquinone Promotes Pancreatic Cancer Cell Death and Reduction of Tumor Size through Combined Inhibition of Histone Deacetylation and Induction of Histone Acetylation
المؤلفون المشاركون
Yeo, Charles J.
Gong, Qiaoke
Relles, Daniel
Chipitsyna, Galina I.
Arafat, Hwyda A.
المصدر
Advances in Preventive Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-26
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Pancreatic ductal adenocarcinoma (PDAC) is virtually therapy-resistant.
As noninvasive lesions progress to malignancy, the precursor period provides a window for cancer therapies that can interfere with neoplastic progression.
Thymoquinone (Tq), a major bioactive component of essential oil from Nigella sativa’s seeds, has demonstrated antineoplastic activities in multiple cancers.
In this study, we investigated antineoplastic potential of Tq in human PDAC cell lines, AsPC-1 and MiaPaCa-2.
Tq (10–50 μM) inhibited cell viability and proliferation and caused partial G2 cycle arrest in dose-dependent manner in both cell lines.
Cells accumulated in subG0/G1 phase, indicating apoptosis.
This was associated with upregulation of p53 and downregulation of Bcl-2.
Independently of p53, Tq increased p21 mRNA expression 12-fold.
Tq also induced H4 acetylation (lysine 12) and downregulated HDACs activity, reducing expression of HDACs 1, 2, and 3 by 40–60%.
In vivo, Tq significantly reduced tumor size in 67% of established tumor xenografts (P<0.05), along with increased H4 acetylation and reduced HDACs expression.
Our results showed that Tq mediated posttranslational modification of histone acetylation, inhibited HDACs expression, and induced proapoptotic signaling pathways.
These molecular targets demonstrate rationale for using Tq as a promising antineoplastic agent to prevent postoperative cancer recurrence and to prolong survival of PDAC patients after surgical resection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Relles, Daniel& Chipitsyna, Galina I.& Gong, Qiaoke& Yeo, Charles J.& Arafat, Hwyda A.. 2016. Thymoquinone Promotes Pancreatic Cancer Cell Death and Reduction of Tumor Size through Combined Inhibition of Histone Deacetylation and Induction of Histone Acetylation. Advances in Preventive Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1096601
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Relles, Daniel…[et al.]. Thymoquinone Promotes Pancreatic Cancer Cell Death and Reduction of Tumor Size through Combined Inhibition of Histone Deacetylation and Induction of Histone Acetylation. Advances in Preventive Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1096601
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Relles, Daniel& Chipitsyna, Galina I.& Gong, Qiaoke& Yeo, Charles J.& Arafat, Hwyda A.. Thymoquinone Promotes Pancreatic Cancer Cell Death and Reduction of Tumor Size through Combined Inhibition of Histone Deacetylation and Induction of Histone Acetylation. Advances in Preventive Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1096601
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1096601
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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