Involvement of Inflammatory Cytokines in Antiarrhythmic Effects of Clofibrate in Ouabain-Induced Arrhythmia in Isolated Rat Atria
المؤلفون المشاركون
Moradi, Somayeh
Imran Khan, Muhammad
Amiri, Shayan
Bakhtiarian, Azam
Nikoui, Vahid
Jazaeri, Farahnaz
المصدر
Advances in Pharmacological and Pharmaceutical Sciences
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-02-10
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Considering the cardioprotective and anti-inflammatory properties of clofibrate, the aim of the present experiment was to investigate the involvement of local and systemic inflammatory cytokines in possible antiarrhythmic effects of clofibrate in ouabain-induced arrhythmia in rats.
Rats were orally treated with clofibrate (300 mg/kg), and ouabain (0.56 mg/kg) was administered to animals intraperitoneally.
After induction of anesthesia, the atria were isolated and the onset of arrhythmia and asystole was recorded.
The levels of inflammatory cytokines in atria were also measured.
Clofibrate significantly postponed the onset of arrhythmia and asystole when compared to control group (P≤0.05 and P≤0.01, resp.).
While ouabain significantly increased the atrial beating rate in control group (P≤0.05), same treatment did not show similar effect in clofibrate-treated group (P>0.05).
Injection of ouabain significantly increased the atrial and systemic levels of all studied inflammatory cytokines (P≤0.05).
Pretreatment with clofibrate could attenuate the ouabain-induced elevation of IL-6 and TNF-α in atria (P≤0.01 and P≤0.05, resp.), as well as ouabain-induced increase in IL-6 in plasma (P≤0.05).
Based on our findings, clofibrate may possess antiarrhythmic properties through mitigating the local and systemic inflammatory factors including IL-6 and TNF-α.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Moradi, Somayeh& Nikoui, Vahid& Imran Khan, Muhammad& Amiri, Shayan& Jazaeri, Farahnaz& Bakhtiarian, Azam. 2016. Involvement of Inflammatory Cytokines in Antiarrhythmic Effects of Clofibrate in Ouabain-Induced Arrhythmia in Isolated Rat Atria. Advances in Pharmacological and Pharmaceutical Sciences،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1096635
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Moradi, Somayeh…[et al.]. Involvement of Inflammatory Cytokines in Antiarrhythmic Effects of Clofibrate in Ouabain-Induced Arrhythmia in Isolated Rat Atria. Advances in Pharmacological and Pharmaceutical Sciences No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1096635
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Moradi, Somayeh& Nikoui, Vahid& Imran Khan, Muhammad& Amiri, Shayan& Jazaeri, Farahnaz& Bakhtiarian, Azam. Involvement of Inflammatory Cytokines in Antiarrhythmic Effects of Clofibrate in Ouabain-Induced Arrhythmia in Isolated Rat Atria. Advances in Pharmacological and Pharmaceutical Sciences. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1096635
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1096635
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر