Pharmacokinetic, Pharmacogenetic, and Other Factors Influencing CNS Penetration of Antiretrovirals

المؤلفون المشاركون

Nwogu, Jacinta Nwamaka
Babalola, Chinedum Peace
Adedeji, Waheed Adeola
Morse, Gene D.
Ma, Qing
Taiwo, Babafemi

المصدر

AIDS Research and Treatment

العدد

المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-13، 13ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2016-09-29

دولة النشر

مصر

عدد الصفحات

13

التخصصات الرئيسية

الأمراض
الطب البشري

الملخص EN

Neurological complications associated with the human immunodeficiency virus (HIV) are a matter of great concern.

While antiretroviral (ARV) drugs are the cornerstone of HIV treatment and typically produce neurological benefit, some ARV drugs have limited CNS penetration while others have been associated with neurotoxicity.

CNS penetration is a function of several factors including sieving role of blood-brain and blood-CSF barriers and activity of innate drug transporters.

Other factors are related to pharmacokinetics and pharmacogenetics of the specific ARV agent or mediated by drug interactions, local inflammation, and blood flow.

In this review, we provide an overview of the various factors influencing CNS penetration of ARV drugs with an emphasis on those commonly used in sub-Saharan Africa.

We also summarize some key associations between ARV drug penetration, CNS efficacy, and neurotoxicity.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Nwogu, Jacinta Nwamaka& Ma, Qing& Babalola, Chinedum Peace& Adedeji, Waheed Adeola& Morse, Gene D.& Taiwo, Babafemi. 2016. Pharmacokinetic, Pharmacogenetic, and Other Factors Influencing CNS Penetration of Antiretrovirals. AIDS Research and Treatment،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1096697

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Nwogu, Jacinta Nwamaka…[et al.]. Pharmacokinetic, Pharmacogenetic, and Other Factors Influencing CNS Penetration of Antiretrovirals. AIDS Research and Treatment No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1096697

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Nwogu, Jacinta Nwamaka& Ma, Qing& Babalola, Chinedum Peace& Adedeji, Waheed Adeola& Morse, Gene D.& Taiwo, Babafemi. Pharmacokinetic, Pharmacogenetic, and Other Factors Influencing CNS Penetration of Antiretrovirals. AIDS Research and Treatment. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1096697

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1096697