![](/images/graphics-bg.png)
Immunogenicity of RSV F DNA Vaccine in BALBc Mice
المؤلفون المشاركون
Bawage, Swapnil Subhash
Eroglu, Erdal
Singh, Ankur
Vig, Komal
Dennis, Vida A.
Pillai, Shreekumar
Tiwari, Pooja Munnilal
Singh, Shree Ram
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-09-05
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Respiratory syncytial virus (RSV) causes severe acute lower respiratory tract disease leading to numerous hospitalizations and deaths among the infant and elderly populations worldwide.
There is no vaccine or a less effective drug available against RSV infections.
Natural RSV infection stimulates the Th1 immune response and activates the production of neutralizing antibodies, while earlier vaccine trials that used UV-inactivated RSV exacerbated the disease due to the activation of the allergic Th2 response.
With a focus on Th1 immunity, we developed a DNA vaccine containing the native RSV fusion (RSV F) protein and studied its immune response in BALB/c mice.
High levels of RSV specific antibodies were induced during subsequent immunizations.
The serum antibodies were able to neutralize RSV in vitro.
The RSV inhibition by sera was also shown by immunofluorescence analyses.
Antibody response of the RSV F DNA vaccine showed a strong Th1 response.
Also, sera from RSV F immunized and RSV infected mice reduced the RSV infection by 50% and 80%, respectively.
Our data evidently showed that the RSV F DNA vaccine activated the Th1 biased immune response and led to the production of neutralizing antibodies, which is the desired immune response required for protection from RSV infections.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Eroglu, Erdal& Singh, Ankur& Bawage, Swapnil Subhash& Tiwari, Pooja Munnilal& Vig, Komal& Pillai, Shreekumar…[et al.]. 2016. Immunogenicity of RSV F DNA Vaccine in BALBc Mice. Advances in Virology،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1096777
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Eroglu, Erdal…[et al.]. Immunogenicity of RSV F DNA Vaccine in BALBc Mice. Advances in Virology No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1096777
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Eroglu, Erdal& Singh, Ankur& Bawage, Swapnil Subhash& Tiwari, Pooja Munnilal& Vig, Komal& Pillai, Shreekumar…[et al.]. Immunogenicity of RSV F DNA Vaccine in BALBc Mice. Advances in Virology. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1096777
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1096777
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)