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Facile Synthesis, Characterization, and Cytotoxic Activity of Europium-Doped Nanohydroxyapatite
المؤلفون المشاركون
Niño Martínez, N.
Miranda-Meléndez, Paulina-Guadalupe
Patiño-Marín, Nuria
Casillas-Santana, Miguel-Ángel
Castillo-Silva, Brenda-Erendida
Martínez-Castañón, G.
Ruiz, Facundo
المصدر
Bioinorganic Chemistry and Applications
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-14
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The objective of this study was to synthetize europium-doped nanohydroxyapatite using a simple aqueous precipitation method and, thereafter, characterize and impregnate selected samples with 5-fluorouracil in order to explore the properties and the releasing capacity of this material.
The nanohydroxyapatite was doped with 3, 5, 10, and 20 wt% of europium.
The obtained samples were characterized after they were dried at 80°C and hydrothermal treated at 120°C by 2 hours.
The samples were analyzed by transmission electron microscopy, X-ray diffraction analysis, Fourier transform infrared spectroscopy, and photoluminescence.
Also, impregnation and release of 5-fluorouracil were assessed in PBS.
The toxicity effects of all samples were studied using viability assays on human fibroblasts cells (HGF-1) in vitro.
The sizes of the crystallites were about 10–70 nm with irregular morphology and present the phase corresponding to the JCPDS card 9–0432 for hydroxyapatite.
The results of the toxicity experiments indicated that doped and undoped powders are biocompatible with fibroblasts cells.
Hydroxyapatite samples doped with 5% of europium and loaded with 5-fluorouracil release almost 7 mg/L of the drug after 60 minutes in PBS and decrease the viability of HeLa cells after 24 hours.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Miranda-Meléndez, Paulina-Guadalupe& Martínez-Castañón, G.& Niño Martínez, N.& Patiño-Marín, Nuria& Casillas-Santana, Miguel-Ángel& Castillo-Silva, Brenda-Erendida…[et al.]. 2016. Facile Synthesis, Characterization, and Cytotoxic Activity of Europium-Doped Nanohydroxyapatite. Bioinorganic Chemistry and Applications،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1096782
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Miranda-Meléndez, Paulina-Guadalupe…[et al.]. Facile Synthesis, Characterization, and Cytotoxic Activity of Europium-Doped Nanohydroxyapatite. Bioinorganic Chemistry and Applications No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1096782
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Miranda-Meléndez, Paulina-Guadalupe& Martínez-Castañón, G.& Niño Martínez, N.& Patiño-Marín, Nuria& Casillas-Santana, Miguel-Ángel& Castillo-Silva, Brenda-Erendida…[et al.]. Facile Synthesis, Characterization, and Cytotoxic Activity of Europium-Doped Nanohydroxyapatite. Bioinorganic Chemistry and Applications. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1096782
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1096782
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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