Protective Effects of Caffeic Acid Phenethyl Ester on Fluoxetine-Induced Hepatotoxicity: An Experimental Study
المؤلفون المشاركون
Yılmaz, Ahmet
Elbey, Bilal
Yazgan, Ümit Can
Dönder, Ahmet
Arslan, Necmi
Arslan, Serkan
Alabalık, Ulaş
Aslanhan, Hamza
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-10
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
The aim of the study was to analyse the effect of caffeic acid phenethyl ester (CAPE) on fluoxetine-induced hepatotoxicity in rats.
Materials and Methods.
Group I served as control.
Group II received CAPE intraperitoneally.
Group III received fluoxetine per orally.
Group IV received fluoxetine and CAPE.
The total antioxidant capacity (TAC), total oxidant status (TOS), oxidative stress index (OSI), and liver enzymes including paraoxonase-1 (PON-1), aspartate transaminase, and alanine transaminase levels were measured.
Liver tissues were processed histopathologically for evaluation of liver injury and to validate the serum enzyme levels.
Results.
An increase in TOS and OSI and a decrease in TAC and PON-1 levels in serum and liver tissues of Group III were observed compared to Groups I and II.
After treatment with CAPE, the level of TOS and OSI decreased while TAC and PON-1 increased in serum and liver in Group IV.
Histopathological examination of the liver revealed hepatic injury after fluoxetine treatment and reduction of injury with CAPE treatment.
Conclusion.
Our results suggested that CAPE treatment provided protection against fluoxetine toxicity.
Following CAPE treatment with fluoxetine-induced hepatotoxicity, TOS and OSI levels decreased, whereas PON-1 and TAC increased in the serum and liver.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yılmaz, Ahmet& Elbey, Bilal& Yazgan, Ümit Can& Dönder, Ahmet& Arslan, Necmi& Arslan, Serkan…[et al.]. 2016. Protective Effects of Caffeic Acid Phenethyl Ester on Fluoxetine-Induced Hepatotoxicity: An Experimental Study. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1096834
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yılmaz, Ahmet…[et al.]. Protective Effects of Caffeic Acid Phenethyl Ester on Fluoxetine-Induced Hepatotoxicity: An Experimental Study. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1096834
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yılmaz, Ahmet& Elbey, Bilal& Yazgan, Ümit Can& Dönder, Ahmet& Arslan, Necmi& Arslan, Serkan…[et al.]. Protective Effects of Caffeic Acid Phenethyl Ester on Fluoxetine-Induced Hepatotoxicity: An Experimental Study. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1096834
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1096834
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر