The Effect of Adipose-Derived Stem Cells on Full-Thickness Skin Grafts
المؤلفون المشاركون
Han, Wei-Dong
Wang, Juan
Hao, Haojie
Huang, Hong
Chen, Deyun
Han, Yan
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-20
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
The purpose of this study was to evaluate the effects of ASCs on full-thickness skin grafts.
Specifically, we investigated the anti-inflammatory effects of ASCs that are mediated via regulation of the phenotypes of activated macrophages.
Methods.
ASCs were isolated, cultured, and injected under full-thickness skin grafts in 15 rats (ASC group).
An additional 15 rats served as controls (PBS group).
Skin graft survival assessment and vascularization detection were assessed with H&E staining and laser Doppler blood flowmetry (LDF).
The effects of ASCs on angiogenesis, anti-inflammation, collagen accumulation-promoting, and antiscarring were assessed.
Results.
We found that the skin graft survival rate was significantly increased in the ASC group.
The neovascularization, collagen deposition, collagen type I to type III ratio, and levels of VEGF and TGF-β3 in the ASC group were markedly higher than those in the PBS group at day 14.
Additionally, in the ASC group, the levels of iNOS, IL-1β, and TNF-α were remarkably decreased, whereas the levels of IL-10 and Arg-1 were substantially increased.
Conclusions.
Our results confirm that ASCs transplantation can effectively improve full-thickness skin graft survival.
Additionally, the anti-inflammatory role of ASCs may indirectly contribute to skin graft survival via its effect on macrophage polarization.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Juan& Hao, Haojie& Huang, Hong& Chen, Deyun& Han, Yan& Han, Wei-Dong. 2016. The Effect of Adipose-Derived Stem Cells on Full-Thickness Skin Grafts. BioMed Research International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1096890
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Juan…[et al.]. The Effect of Adipose-Derived Stem Cells on Full-Thickness Skin Grafts. BioMed Research International No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1096890
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Juan& Hao, Haojie& Huang, Hong& Chen, Deyun& Han, Yan& Han, Wei-Dong. The Effect of Adipose-Derived Stem Cells on Full-Thickness Skin Grafts. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1096890
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1096890
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر