![](/images/graphics-bg.png)
Phosphorylated and Nonphosphorylated PfMAP2 Are Localized in the Nucleus, Dependent on the Stage of Plasmodium falciparum Asexual Maturation
المؤلفون المشاركون
Dahalan, Farah Aida
Sidek, Hasidah Mohd
Murtey, Mogana Das
Embi, Mohammed Noor
Ibrahim, Jamaiah
Fei Tieng, Lim
Zakaria, Nurul Aiezzah
Abdul-Aziz, Noraishah Mydin
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-07-25
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Plasmodium falciparum mitogen-activated protein (MAP) kinases, a family of enzymes central to signal transduction processes including inflammatory responses, are a promising target for antimalarial drug development.
Our study shows for the first time that the P.
falciparum specific MAP kinase 2 (PfMAP2) is colocalized in the nucleus of all of the asexual erythrocytic stages of P.
falciparum and is particularly elevated in its phosphorylated form.
It was also discovered that PfMAP2 is expressed in its highest quantity during the early trophozoite (ring form) stage and significantly reduced in the mature trophozoite and schizont stages.
Although the phosphorylated form of the kinase is always more prevalent, its ratio relative to the nonphosphorylated form remained constant irrespective of the parasites’ developmental stage.
We have also shown that the TSH motif specifically renders PfMAP2 genetically divergent from the other plasmodial MAP kinase activation sites using Neighbour Joining analysis.
Furthermore, TSH motif-specific designed antibody is crucial in determining the location of the expression of the PfMAP2 protein.
However, by using immunoelectron microscopy, PPfMAP2 were detected ubiquitously in the parasitized erythrocytes.
In summary, PfMAP2 may play a far more important role than previously thought and is a worthy candidate for research as an antimalarial.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dahalan, Farah Aida& Sidek, Hasidah Mohd& Murtey, Mogana Das& Embi, Mohammed Noor& Ibrahim, Jamaiah& Fei Tieng, Lim…[et al.]. 2016. Phosphorylated and Nonphosphorylated PfMAP2 Are Localized in the Nucleus, Dependent on the Stage of Plasmodium falciparum Asexual Maturation. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1096928
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dahalan, Farah Aida…[et al.]. Phosphorylated and Nonphosphorylated PfMAP2 Are Localized in the Nucleus, Dependent on the Stage of Plasmodium falciparum Asexual Maturation. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1096928
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dahalan, Farah Aida& Sidek, Hasidah Mohd& Murtey, Mogana Das& Embi, Mohammed Noor& Ibrahim, Jamaiah& Fei Tieng, Lim…[et al.]. Phosphorylated and Nonphosphorylated PfMAP2 Are Localized in the Nucleus, Dependent on the Stage of Plasmodium falciparum Asexual Maturation. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1096928
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1096928
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)