Preparation and In Vivo Pharmacokinetics of the Tongshu Suppository
المؤلفون المشاركون
Liu, Guoqiang
Dong, Leilei
Lu, Kuan
Liu, Sisi
Zheng, Yingying
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-16
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Astragalus polysaccharide (APS) (used for intestinal protection) was added to formulate the Tongshu suppository to improve the pharmacokinetics of Aceclofenac, which were assessed in New Zealand rabbits using an orthogonal experimental design.
The single-agent Aceclofenac was taken as the control formulation.
The concentration-time and drug release curves were drawn, and Tmax (min), Cmax (μg·mL−1), AUC0→∞, and MRT were compared using a pharmacokinetic systems program.
The formulated Tongshu suppository had moderate hardness, a smooth surface with uniform color, and theoretical drug-loading rate of 8%.
Its release rate was in accordance with the drug preparation requirements.
The concentration-time curves and drug release curves revealed that the maximum concentrations (Cmax) were 4.18±1.03 μg·mL−1 and 3.34±0.41 μg·mL−1 for the Tongshu and Aceclofenac suppositories, respectively, showing statistically insignificant difference, while the peak times were 34.87±4.69 min and 34.76±6.34 min, respectively, also showing statistically insignificant difference.
Compared with the Aceclofenac suppository, the relative bioavailability of the Tongshu suppository was 104.4%, and the difference between them was statistically insignificant.
In this experiment, the Tongshu suppository was prepared using the hot-melt method.
In vivo pharmacokinetic studies confirmed it had higher bioavailability than the Aceclofenac suppository.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Guoqiang& Dong, Leilei& Lu, Kuan& Liu, Sisi& Zheng, Yingying. 2016. Preparation and In Vivo Pharmacokinetics of the Tongshu Suppository. BioMed Research International،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1096940
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Guoqiang…[et al.]. Preparation and In Vivo Pharmacokinetics of the Tongshu Suppository. BioMed Research International No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1096940
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Guoqiang& Dong, Leilei& Lu, Kuan& Liu, Sisi& Zheng, Yingying. Preparation and In Vivo Pharmacokinetics of the Tongshu Suppository. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1096940
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1096940
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر