Oxymatrine Inhibits Proliferation and Migration While Inducing Apoptosis in Human Glioblastoma Cells

المؤلفون المشاركون

Liu, Feili
Wang, Baocheng
Wang, Jiajia
Ling, Xiaozheng
Li, Qifeng
Meng, Wei
Ma, Jie

المصدر

BioMed Research International

العدد

المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2016-11-13

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الطب البشري

الملخص EN

Oxymatrine (OMT), an alkaloid derived from the traditional Chinese medicine herb Sophora flavescens Aiton, has been shown to exhibit anticancer properties on various types of cancer cells.

In this study, we investigate the anticancer properties of OMT on human glioblastoma (GBM) cells and evaluate their underlying mechanisms.

MTT assays were performed and demonstrated that OMT significantly inhibits the proliferation of GBM cells.

Flow cytometry suggested that OMT at a concentration of 10−5 M may induce apoptosis in U251 and A172 cells.

Western blot analyses demonstrated a significant increase in the expression of Bax and caspase-3 and a significant decrease in expression of Bcl-2 in both U251 and A172 cells.

Additionally, OMT was found by transwell and high-content screening assays to decrease the migratory ability of the evaluated GBM cells.

These findings suggest that the antitumor effects of OMT may be the result of inhibition of cell proliferation and migration and the induction of apoptosis by regulating the expression of apoptosis-associated proteins.

OMT may represent a novel anticancer therapy for the treatment of GBM.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Liu, Feili& Wang, Baocheng& Wang, Jiajia& Ling, Xiaozheng& Li, Qifeng& Meng, Wei…[et al.]. 2016. Oxymatrine Inhibits Proliferation and Migration While Inducing Apoptosis in Human Glioblastoma Cells. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1096966

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Liu, Feili…[et al.]. Oxymatrine Inhibits Proliferation and Migration While Inducing Apoptosis in Human Glioblastoma Cells. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1096966

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Liu, Feili& Wang, Baocheng& Wang, Jiajia& Ling, Xiaozheng& Li, Qifeng& Meng, Wei…[et al.]. Oxymatrine Inhibits Proliferation and Migration While Inducing Apoptosis in Human Glioblastoma Cells. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1096966

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1096966