Advances in Engineered Liver Models for Investigating Drug-Induced Liver Injury
المؤلفون المشاركون
Lin, Christine
Khetani, Salman R.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-20، 20ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-09-20
دولة النشر
مصر
عدد الصفحات
20
التخصصات الرئيسية
الملخص EN
Drug-induced liver injury (DILI) is a major cause of drug attrition.
Testing drugs on human liver models is essential to mitigate the risk of clinical DILI since animal studies do not always suffice due to species-specific differences in liver pathways.
While primary human hepatocytes (PHHs) can be cultured on extracellular matrix proteins, a rapid decline in functions leads to low sensitivity (<50%) in DILI prediction.
Semiconductor-driven engineering tools now allow precise control over the hepatocyte microenvironment to enhance and stabilize phenotypic functions.
The latest platforms coculture PHHs with stromal cells to achieve hepatic stability and enable crosstalk between the various liver cell types towards capturing complex cellular mechanisms in DILI.
The recent introduction of induced pluripotent stem cell-derived human hepatocyte-like cells can potentially allow a better understanding of interindividual differences in idiosyncratic DILI.
Liver models are also being coupled to other tissue models via microfluidic perfusion to study the intertissue crosstalk upon drug exposure as in a live organism.
Here, we review the major advances being made in the engineering of liver models and readouts as they pertain to DILI investigations.
We anticipate that engineered human liver models will reduce drug attrition, animal usage, and cases of DILI in humans.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lin, Christine& Khetani, Salman R.. 2016. Advances in Engineered Liver Models for Investigating Drug-Induced Liver Injury. BioMed Research International،Vol. 2016, no. 2016, pp.1-20.
https://search.emarefa.net/detail/BIM-1096978
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lin, Christine& Khetani, Salman R.. Advances in Engineered Liver Models for Investigating Drug-Induced Liver Injury. BioMed Research International No. 2016 (2016), pp.1-20.
https://search.emarefa.net/detail/BIM-1096978
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lin, Christine& Khetani, Salman R.. Advances in Engineered Liver Models for Investigating Drug-Induced Liver Injury. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-20.
https://search.emarefa.net/detail/BIM-1096978
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1096978
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر