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Early Administration of Glutamine Protects Cardiomyocytes from Post-Cardiac Arrest Acidosis
المؤلفون المشاركون
Lin, Yan-Ren
Li, Chao-Jui
Syu, Shih-Han
Wen, Cheng-Hao
Buddhakosai, Waradee
Hsu Chen, Cheng
Lu, Huai-En
Chen, Wen-Liang
Wu, Han P.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-12
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Postcardiac arrest acidosis can decrease survival.
Effective medications without adverse side effects are still not well characterized.
We aimed to analyze whether early administration of glutamine could improve survival and protect cardiomyocytes from postcardiac arrest acidosis using animal and cell models.
Forty Wistar rats with postcardiac arrest acidosis (blood pH < 7.2) were included.
They were divided into study (500 mg/kg L-alanyl-L-glutamine, n=20) and control (normal saline, n=20) groups.
Each of the rats received resuscitation.
The outcomes were compared between the two groups.
In addition, cardiomyocytes derived from human induced pluripotent stem cells were exposed to HBSS with different pH levels (7.3 or 6.5) or to culture medium (control).
Apoptosis-related markers and beating function were analyzed.
We found that the duration of survival was significantly longer in the study group (p<0.05).
In addition, in pH 6.5 or pH 7.3 HBSS buffer, the expression levels of cell stress (p53) and apoptosis (caspase-3, Bcl-xL) markers were significantly lower in cardiomyocytes treated with 50 mM L-glutamine than those without L-glutamine (RT-PCR).
L-glutamine also increased the beating function of cardiomyocytes, especially at the lower pH level (6.5).
More importantly, glutamine decreased cardiomyocyte apoptosis and increased these cells’ beating function at a low pH level.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lin, Yan-Ren& Li, Chao-Jui& Syu, Shih-Han& Wen, Cheng-Hao& Buddhakosai, Waradee& Wu, Han P.…[et al.]. 2016. Early Administration of Glutamine Protects Cardiomyocytes from Post-Cardiac Arrest Acidosis. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1097034
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lin, Yan-Ren…[et al.]. Early Administration of Glutamine Protects Cardiomyocytes from Post-Cardiac Arrest Acidosis. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1097034
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lin, Yan-Ren& Li, Chao-Jui& Syu, Shih-Han& Wen, Cheng-Hao& Buddhakosai, Waradee& Wu, Han P.…[et al.]. Early Administration of Glutamine Protects Cardiomyocytes from Post-Cardiac Arrest Acidosis. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1097034
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1097034
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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