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Potential Diagnostic and Prognostic Biomarkers of Epigenetic Drift within the Cardiovascular Compartment
المؤلفون المشاركون
Wallace, Robert G.
Twomey, Laura C.
Custaud, Marc-Antoine
Cummins, Philip M.
Mangone, Marco
Murphy, Ronan P.
Moyna, Niall M.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-28
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Biomarkers encompass a wide range of different measurable indicators, representing a tangible link to physiological changes occurring within the body.
Accessibility, sensitivity, and specificity are significant factors in biomarker suitability.
New biomarkers continue to be discovered, and questions over appropriate selection and assessment of their usefulness remain.
If traditional markers of inflammation are not sufficiently robust in their specificity, then perhaps alternative means of detection may provide more information.
Epigenetic drift (epigenetic modifications as they occur as a direct function with age), and its ancillary elements, including platelets, secreted microvesicles (MVs), and microRNA (miRNA), may hold enormous predictive potential.
The majority of epigenetic drift observed in blood is independent of variations in blood cell composition, addressing concerns affecting traditional blood-based biomarker efficacy.
MVs are found in plasma and other biological fluids in healthy individuals.
Altered MV/miRNA profiles may also be found in individuals with various diseases.
Platelets are also highly reflective of physiological and lifestyle changes, making them extremely sensitive biomarkers of human health.
Platelets release increased levels of MVs in response to various stimuli and under a plethora of disease states, which demonstrate a functional effect on other cell types.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wallace, Robert G.& Twomey, Laura C.& Custaud, Marc-Antoine& Moyna, Niall M.& Cummins, Philip M.& Mangone, Marco…[et al.]. 2016. Potential Diagnostic and Prognostic Biomarkers of Epigenetic Drift within the Cardiovascular Compartment. BioMed Research International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1097075
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wallace, Robert G.…[et al.]. Potential Diagnostic and Prognostic Biomarkers of Epigenetic Drift within the Cardiovascular Compartment. BioMed Research International No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1097075
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wallace, Robert G.& Twomey, Laura C.& Custaud, Marc-Antoine& Moyna, Niall M.& Cummins, Philip M.& Mangone, Marco…[et al.]. Potential Diagnostic and Prognostic Biomarkers of Epigenetic Drift within the Cardiovascular Compartment. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1097075
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1097075
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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