Inflammation Related MicroRNAs Are Modulated in Total Plasma and in Extracellular Vesicles from Rats with Chronic Ingestion of Sucrose
المؤلفون المشاركون
Sánchez, Fausto
Brianza-Padilla, Malinalli
Carbó, Roxana
Arana, Julio C.
Vázquez-Palacios, Gonzalo
Ballinas-Verdugo, Martha A.
Cardoso-Saldaña, Guillermo C.
Palacio, Adán G.
Juárez-Vicuña, Yaneli
Martínez-Martínez, Eduardo
Huang, Fengyang
Bojalil, Rafael
Sanchez-Muñoz, Fausto
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-24
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Circulating microRNAs (miRNAs) and the functional implications of miRNAs contained in extracellular vesicles (EVs) have gained attention in the last decade.
Little is known about the regulation of the abundance of plasma miRNAs in response to chronic ingestion of carbohydrates.
Therefore, we explored the circulating levels of miR-21, miR-146a, miR-155, and miR-223 in rats consuming sucrose in drinking water.
Weanling Wistar rats were 25 weeks with 30% sucrose in drinking water, and miRNAs expression was determined in total plasma and in microvesicles, by RT-qPCR with TaqMan probe based assays for miR-21, miR-146a, miR-155, and miR-223, using cel-miR-39 (as spike in control and reference).
Endotoxemia was also measured.
Sucrose-fed animals showed higher body weight and retroperitoneal adipose tissue as well as higher glucose and triglyceride plasma levels than controls.
Plasma endotoxin levels were low and not different among groups.
Plasma miR-21 and miR-223 were higher in the sucrose group (p<0.05), whereas miR-155 tended to be lower (p=0.0661), and miR-146a did not show significant differences.
In the plasma EVs the same trend was found except for miR-146a that showed significantly higher levels (p<0.05).
Overall, our results show that high carbohydrate ingestion modulates circulating miRNAs levels related to an inflammatory response.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Brianza-Padilla, Malinalli& Carbó, Roxana& Arana, Julio C.& Vázquez-Palacios, Gonzalo& Ballinas-Verdugo, Martha A.& Cardoso-Saldaña, Guillermo C.…[et al.]. 2016. Inflammation Related MicroRNAs Are Modulated in Total Plasma and in Extracellular Vesicles from Rats with Chronic Ingestion of Sucrose. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1097083
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Brianza-Padilla, Malinalli…[et al.]. Inflammation Related MicroRNAs Are Modulated in Total Plasma and in Extracellular Vesicles from Rats with Chronic Ingestion of Sucrose. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1097083
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Brianza-Padilla, Malinalli& Carbó, Roxana& Arana, Julio C.& Vázquez-Palacios, Gonzalo& Ballinas-Verdugo, Martha A.& Cardoso-Saldaña, Guillermo C.…[et al.]. Inflammation Related MicroRNAs Are Modulated in Total Plasma and in Extracellular Vesicles from Rats with Chronic Ingestion of Sucrose. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1097083
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1097083
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر