Comparison of FDA Approved Kinase Targets to Clinical Trial Ones: Insights from Their System Profiles and Drug-Target Interaction Networks
المؤلفون المشاركون
Xu, Jingyu
Wang, Panpan
Yang, Hong
Zhou, Jin
Li, Yinghong
Li, Xiaoxu
Xue, Weiwei
Yu, Chunyan
Tian, Yubin
Zhu, Feng
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-07-28
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Kinase is one of the most productive classes of established targets, but the majority of approved drugs against kinase were developed only for cancer.
Intensive efforts were therefore exerted for releasing its therapeutic potential by discovering new therapeutic area.
Kinases in clinical trial could provide great opportunities for treating various diseases.
However, no systematic comparison between system profiles of established targets and those of clinical trial ones was conducted.
The reveal of probable difference or shift of trend would help to identify key factors defining druggability of established targets.
In this study, a comparative analysis of system profiles of both types of targets was conducted.
Consequently, the systems profiles of the majority of clinical trial kinases were identified to be very similar to those of established ones, but percentages of established targets obeying the system profiles appeared to be slightly but consistently higher than those of clinical trial targets.
Moreover, a shift of trend in the system profiles from the clinical trial to the established targets was identified, and popular kinase targets were discovered.
In sum, this comparative study may help to facilitate the identification of the druggability of established drug targets by their system profiles and drug-target interaction networks.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Jingyu& Wang, Panpan& Yang, Hong& Zhou, Jin& Li, Yinghong& Li, Xiaoxu…[et al.]. 2016. Comparison of FDA Approved Kinase Targets to Clinical Trial Ones: Insights from Their System Profiles and Drug-Target Interaction Networks. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1097091
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Jingyu…[et al.]. Comparison of FDA Approved Kinase Targets to Clinical Trial Ones: Insights from Their System Profiles and Drug-Target Interaction Networks. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1097091
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Jingyu& Wang, Panpan& Yang, Hong& Zhou, Jin& Li, Yinghong& Li, Xiaoxu…[et al.]. Comparison of FDA Approved Kinase Targets to Clinical Trial Ones: Insights from Their System Profiles and Drug-Target Interaction Networks. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1097091
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1097091
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر