An Efficient Approach to Screening Epigenome-Wide Data

المؤلفون المشاركون

Karmaus, Wilfried J.
Ray, Meredith A.
Tong, Xin
Lockett, Gabrielle A.
Zhang, Hongmei

المصدر

BioMed Research International

العدد

المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-16، 16ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2016-03-13

دولة النشر

مصر

عدد الصفحات

16

التخصصات الرئيسية

الطب البشري

الملخص EN

Screening cytosine-phosphate-guanine dinucleotide (CpG) DNA methylation sites in association with some covariate(s) is desired due to high dimensionality.

We incorporate surrogate variable analyses (SVAs) into (ordinary or robust) linear regressions and utilize training and testing samples for nested validation to screen CpG sites.

SVA is to account for variations in the methylation not explained by the specified covariate(s) and adjust for confounding effects.

To make it easier to users, this screening method is built into a user-friendly R package, ttScreening, with efficient algorithms implemented.

Various simulations were implemented to examine the robustness and sensitivity of the method compared to the classical approaches controlling for multiple testing: the false discovery rates-based (FDR-based) and the Bonferroni-based methods.

The proposed approach in general performs better and has the potential to control both types I and II errors.

We applied ttScreening to 383,998 CpG sites in association with maternal smoking, one of the leading factors for cancer risk.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Ray, Meredith A.& Tong, Xin& Lockett, Gabrielle A.& Zhang, Hongmei& Karmaus, Wilfried J.. 2016. An Efficient Approach to Screening Epigenome-Wide Data. BioMed Research International،Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1097118

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Ray, Meredith A.…[et al.]. An Efficient Approach to Screening Epigenome-Wide Data. BioMed Research International No. 2016 (2016), pp.1-16.
https://search.emarefa.net/detail/BIM-1097118

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Ray, Meredith A.& Tong, Xin& Lockett, Gabrielle A.& Zhang, Hongmei& Karmaus, Wilfried J.. An Efficient Approach to Screening Epigenome-Wide Data. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1097118

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1097118