The Expression of NOX4 in Smooth Muscles of Small Airway Correlates with the Disease Severity of COPD
المؤلفون المشاركون
He, Jinxi
Liu, Xiaoming
Liu, Xianyan
Hao, Binwei
Ma, Ailing
Chen, Juan
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-30
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Airway smooth muscle (ASM) remodeling is a hallmark in chronic obstructive pulmonary disease (COPD), and nicotinamide-adenine dinucleotide phosphate (NADPH) oxidases (NOXs) produced reactive oxygen species (ROS) play a crucial role in COPD pathogenesis.
In the present study, the expression of NOX4 and its correlation with the ASM hypertrophy/hyperplasia, clinical pulmonary functions, and the expression of transforming growth factor β (TGF-β) in the ASM of COPD small airways were investigated by semiquantitative morphological and/or immunohistochemistry staining methods.
The results showed that an elevated expression of NOX4 and TGF-β, along with an increased volume of ASM mass, was found in the ASM of small airways in COPD patients.
The abundance of NOX4 protein in the ASM was increased with disease severity and inversely correlated with the pulmonary functions in COPD patients.
In addition, the expression of NOX4 and ASM marker α-SMA was colocalized, and the increased NOX4 expression was found to accompany an upregulated expression of TGF-β in the ASM of small airways of COPD lung.
These results indicate that NOX4 may be a key regulator in ASM remodeling of small airway, in part through a mechanism interacting with TGF-β signaling in the pathogenesis of COPD, which warrants further investigation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Xianyan& Hao, Binwei& Ma, Ailing& He, Jinxi& Liu, Xiaoming& Chen, Juan. 2016. The Expression of NOX4 in Smooth Muscles of Small Airway Correlates with the Disease Severity of COPD. BioMed Research International،Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1097183
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Xianyan…[et al.]. The Expression of NOX4 in Smooth Muscles of Small Airway Correlates with the Disease Severity of COPD. BioMed Research International No. 2016 (2016), pp.1-17.
https://search.emarefa.net/detail/BIM-1097183
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Xianyan& Hao, Binwei& Ma, Ailing& He, Jinxi& Liu, Xiaoming& Chen, Juan. The Expression of NOX4 in Smooth Muscles of Small Airway Correlates with the Disease Severity of COPD. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1097183
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1097183
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر