Jacalin-Activated Macrophages Exhibit an Antitumor Phenotype
المؤلفون المشاركون
Pereira-da-Silva, Gabriela
Morais, Fabiana R.
Danella Polli, Cláudia
Pereira Ruas, Luciana
Chain Veronez, Luciana
Herrero Geraldino, Thais
Roque-Barreira, Maria Cristina
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-29
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Tumor-associated macrophages (TAMs) have an ambiguous and complex role in the carcinogenic process, since these cells can be polarized into different phenotypes (proinflammatory, antitumor cells or anti-inflammatory, protumor cells) by the tumor microenvironment.
Given that the interactions between tumor cells and TAMs involve several players, a better understanding of the function and regulation of TAMs is crucial to interfere with their differentiation in attempts to skew TAM polarization into cells with a proinflammatory antitumor phenotype.
In this study, we investigated the modulation of macrophage tumoricidal activities by the lectin jacalin.
Jacalin bound to macrophage surface and induced the expression and/or release of mainly proinflammatory cytokines via NF-κB signaling, as well as increased iNOS mRNA expression, suggesting that the lectin polarizes macrophages toward the antitumor phenotype.
Therefore, tumoricidal activities of jacalin-stimulated macrophages were evaluated.
High rates of tumor cell (human colon, HT-29, and breast, MCF-7, cells) apoptosis were observed upon incubation with supernatants from jacalin-stimulated macrophages.
Taken together, these results indicate that jacalin, by exerting a proinflammatory activity, can direct macrophages to an antitumor phenotype.
Deep knowledge of the regulation of TAM functions is essential for the development of innovative anticancer strategies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Danella Polli, Cláudia& Pereira Ruas, Luciana& Chain Veronez, Luciana& Herrero Geraldino, Thais& Morais, Fabiana R.& Roque-Barreira, Maria Cristina…[et al.]. 2016. Jacalin-Activated Macrophages Exhibit an Antitumor Phenotype. BioMed Research International،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1097195
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Danella Polli, Cláudia…[et al.]. Jacalin-Activated Macrophages Exhibit an Antitumor Phenotype. BioMed Research International No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1097195
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Danella Polli, Cláudia& Pereira Ruas, Luciana& Chain Veronez, Luciana& Herrero Geraldino, Thais& Morais, Fabiana R.& Roque-Barreira, Maria Cristina…[et al.]. Jacalin-Activated Macrophages Exhibit an Antitumor Phenotype. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1097195
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1097195
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر